Authorship and contributorship
Allergens, germs and asthma
Article first published online: 15 APR 2014
© 2014 The Author. The Clinical Respiratory Journal published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
The Clinical Respiratory Journal
How to Cite
Scadding, G. K. (2014), Allergens, germs and asthma. The Clinical Respiratory Journal. doi: 10.1111/crj.12128
Glenis K. Scadding is the sole author.
Conflict of interest
The authors have stated explicitly that there are no conflicts of interest in connection with this article.
- Article first published online: 15 APR 2014
- Accepted manuscript online: 10 MAR 2014 04:10AM EST
- Manuscript Accepted: 2 MAR 2014
- Manuscript Revised: 3 FEB 2014
- Manuscript Received: 17 SEP 2013
- airway epithelium;
- asthma mechanisms;
- bacterial infection;
- viral infection
To explore asthma pathogenesis using data from upper and lower airways.
English-language papers on human asthma and nasal polyp subjects from 1990 onwards.
High-quality studies in established journals.
The recognition of its inflammatory nature led to a quantum leap in the understanding and treatment of asthma, with lives saved by inhaled corticosteroids. Further work at genetic, molecular, histological and clinical levels has shown that asthma is polymorphic and rarely involves isolated Th2 bronchial inflammation.
Viral infections may act as an initiating event in children and adults, showing synergy with atopy. Chronic staphylococcal colonization of the mucosa may act as a promoter, as in atopic dermatitis. These two observations may be linked, with viruses providing an entry for bacteria into the mucosal epithelium.
Most asthma begins in the nose and involves allergy and infection: both viral and bacterial. The combination of atopy and infection suggests new possibilities for therapy.