Reduction of lipid-laden macrophage index after laparoscopic Nissen fundoplication in cystic fibrosis patients after lung transplantation


  • Conflict of interest: There is no conflict of interest for any of the authors with any companies and/or organizations whose products and/or services may be discussed in this article.

Corresponding author: Don Hayes Jr, MD, MS, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA.

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Lipid-laden macrophage (LLM) index could be potentially useful in assessing gastroesophageal (GE) reflux and aspiration after lung transplantation (LT) in patients with cystic fibrosis (CF).


A retrospective review of CF patients undergoing LT and/or laparoscopic Nissen fundoplication (LNF) from January 1, 2009, to December 31, 2011, was performed.


Seventeen CF patients (nine women), mean (±SD) age 27.9 ± 7.5 yr, underwent LT with mean (±SD) pre-transplant FEV1 of 20.9 ± 5.0% predicted. Seventy percentage (12/17) of patients underwent LNF without complications within 1–2 wk of LT. After LT, but prior to antireflux surgery, there was no significant difference in the mean (±SD) baseline LLM index (154 ± 41 vs. 146 ± 51, p = NS) between patients who were to undergo LNF and patients who did not. After LNF, a significant reduction in the mean (±SD) LLM index occurred following the procedure (154 ± 41–74 ± 54, p < 0.0001) while each patient reported resolution of symptoms of GE reflux, whereas 40% (2/5) undergoing only medical treatment reported resolution of symptoms.


Significant reduction in the LLM index occurred after LNF in CF patients after LT that correlated with resolution of clinical symptoms of GE reflux.