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Impact of recipient age on whole organ pancreas transplantation

Authors


  • Conflict of interest: None.

Corresponding author: Jonathan A. Fridell, MD, Associate Professor, Department of Surgery, Indiana University School of Medicine, 550 N University Blvd, #4258, Indianapolis, IN 46202, USA.

Tel.: 317 944 4370; fax: 317 948 3268; e-mail: jfridell@iupui.edu

Abstract

Aim

The goal of this study was to assess the impact of recipient age on post-transplant outcome.

Methods

All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates.

Results

Patients (n = 405) were divided by decade: <30 yr (n = 37), 30–39 (n = 109), 40–49 (n = 156), 50–59 (n = 85), and ≥60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74%), while all other groups were similar around 80% (p = NS).

Conclusion

No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.

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