Conflict of interest: The authors have no conflicts of interest to disclose.
Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection
Version of Record online: 30 DEC 2012
© 2012 John Wiley & Sons A/S
Volume 27, Issue 1, pages E64–E71, January–February 2013
How to Cite
Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection., , , , , .
- Issue online: 28 JAN 2013
- Version of Record online: 30 DEC 2012
- Manuscript Accepted: 17 OCT 2012
- National Heart, Lung, and Blood Institute/National Institutes of Health. Grant Numbers: T32HL007185, F32HL107003
- adenoviridae infections;
- graft rejection;
- lung transplantation;
- paramyxoviridae infections;
- picornaviridae infections
Community acquired respiratory virus (CARV) infections in lung transplant recipients (LTR) have been associated with adverse outcomes, including acute rejection (AR) and decline in allograft function, in some but not in all studies.
Spirometry and transbronchial biopsy results of LTR diagnosed with CARV infection over a two-yr period were extracted from clinical records. Primary outcomes, studied at 1–2.5 months postinfection, were as follows: (i) incidence of biopsy-proven AR (grade >A0) and (ii) allograft function, defined by forced expiratory volume in one s (FEV1). A reference group of biopsies (n = 526) collected during the study period established the baseline incidence of AR. Rhinovirus (RV) and non-rhinovirus (non-RV) infections were analyzed as subgroups.
Eighty-seven cases of CARV infection were identified in 59 subjects. Incidences of AR were similar in the post-CARV and reference groups and did not differ significantly after RV vs. non-RV infection. Allograft function declined significantly after non-RV infection, but not after RV infection.
In LTR, CARV infections other than RV are associated with allograft dysfunction at 1–2.5 months after infection. However, CARVs do not appear associated with AR at this time point. The impact of specific CARVs on lung allografts, including the development of chronic allograft rejection, merits further study.