Conflicts of interest: The authors declare that there is no conflict of interests regarding the publication of this article.
Negative outcomes after liver transplantation in patients with alcoholic liver disease beyond the fifth post-transplant year
Article first published online: 22 AUG 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 28, Issue 10, pages 1112–1120, October 2014
How to Cite
Negative outcomes after liver transplantation in patients with alcoholic liver disease beyond the fifth post-transplant year., , , , , , , , , .
- Issue published online: 18 OCT 2014
- Article first published online: 22 AUG 2014
- Accepted manuscript online: 25 JUL 2014 01:05AM EST
- Manuscript Accepted: 20 JUL 2014
- alcoholic liver disease;
- liver transplantation;
- outcome assessment;
Although up to 50% of patients with alcoholic liver disease (ALD) resume alcohol consumption after liver transplantation (LT), numerous studies indicate that long-term results are not compromised. This study focused on evaluating the impact of ALD on outcomes up to and beyond the fifth year after LT. Among the 432 primary LT recipients included in this study, 97 underwent transplantation for ALD. Alcohol relapse rate at 10 yr was 33.5%, with younger recipient age being the only independent predictor (p = 0.019). Survival of patients with ALD (77.0%) was similar to those without (79.0%) up to the fifth post-transplant year (p = 0.655) but worse during the five subsequent years among the five-yr survivors (70.6% vs. 92.9%; p = 0.002). ALD was an independent risk factor for poorer survival beyond the fifth post-transplant year (p = 0.049), but not earlier (p = 0.717). Conversely, alcohol relapse increased the risk of death only during the first five post-transplant years (p = 0.039). There were no significant differences regarding graft failure incidence between ALD and non-ALD recipients up to the fifth post-transplant year (7.3% vs. 11.6%; p = 0.255) and beyond (12.9% vs. 5.0%; p = 0.126). In conclusion, pre-transplant diagnosis of ALD yields negative effects on post-transplant outcomes beyond the fifth post-transplant year, not attributable to recidivism.