This study was supported in part by the Clinical Research Foundation.
Moderate Oxidative Stress and High Antioxidative Activity Are Associated with Steatosis in Japanese Males
Article first published online: 6 DEC 2012
© 2012 Wiley Periodicals, Inc.
Clinical and Translational Science
Volume 6, Issue 1, pages 45–49, February 2013
How to Cite
Imatoh, T., Kamimura, S. and Tanihara, S. (2013), Moderate Oxidative Stress and High Antioxidative Activity Are Associated with Steatosis in Japanese Males. Clinical and Translational Science, 6: 45–49. doi: 10.1111/cts.12007
- Issue published online: 11 FEB 2013
- Article first published online: 6 DEC 2012
- Clinical Research Foundation
- liver disease;
Background and aim
Steatosis is an increasingly common problem worldwide, accompanying increasing obesity. Recently, it has been suggested that oxidative stress plays an important role in development of fatty liver disease. We carried out an epidemiological study to clarify the role of oxidative stress and antioxidative activity in steatosis.
This study was conducted with 184 male workers who had received their annual health checkup. Steatosis was confirmed using ultrasonography. Oxidative stress and antioxidative activity were assessed using the dROM test and the BAP test, respectively.
Steatosis was confirmed in 59 subjects (29.7%) by ultrasonography. There was no significant difference between cases and controls in BAP levels (2229.0 μmol/L vs. 2194.3μmol/L, p = 0.83). The steatosis group showed significantly lower dROM levels than the control group (332.7 U. CARR vs. 316.8 U. CARR, p < 0.05). In addition, we carried out logistic regression analysis to assess the combination between dROM levels and BAP levels. Subjects with high dROM levels and high BAP levels had 74% lower risk for steatosis than subjects with low dROM levels and high BAP levels.
Our results suggested that moderate oxidative stress and high antioxidative activity was associated with decreased steatosis risk in Japanese males. Clin Trans Sci 2013; Volume 6: 45–49