Assessing the Impact of the NIH CTSA Program on Institutionally Sponsored Clinical Trials
Article first published online: 18 APR 2013
© 2013 Wiley Periodicals, Inc.
Clinical and Translational Science
Volume 6, Issue 3, pages 196–200, June 2013
How to Cite
Liu, G., Chen, G., Sinoway, L. I. and Berg, A. (2013), Assessing the Impact of the NIH CTSA Program on Institutionally Sponsored Clinical Trials. Clinical and Translational Science, 6: 196–200. doi: 10.1111/cts.12029
- Issue published online: 10 JUN 2013
- Article first published online: 18 APR 2013
- National Center for Advancing Translational Sciences (NCATS). Grant Number: UL1 TR000127
- clinical and translational science;
- clinical trials
To assess the impact of the NIH CTSA program on patient enrollment in clinical trials sponsored/collaborated by CTSA consortium institutions.
Material and Methods
Using publicly available clinical trial data at ClinicalTrials.gov, we identify positive trend changes in the number of patients enrolled in clinical trials performed at CTSA consortium institutions over the years before and after their respective CTSA award dates. CTSA consortium institutions were matched with similar non-CTSA institutions.
As compared to matched non-CTSA institutions CTSA consortium sites noted an increase in patient enrollment after the CTSA awards. In particular, we detected a change-point, where a new enrollment trend emerged, 338 days after the CTSA award. No such trend was noted over the same period in the non-CTSA institutions.
Our analysis provides evidence that the NIH CTSA funding program made a positive impact on patient enrollment.