Equal contributors to this article, in alphabetical order.
Collaborative Approach in the Development of High-Performance Brain–Computer Interfaces for a Neuroprosthetic Arm: Translation from Animal Models to Human Control
Article first published online: 27 AUG 2013
Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
Clinical and Translational Science
Volume 7, Issue 1, pages 52–59, February 2014
How to Cite
Collinger, J. L., Kryger, M. A., Barbara, R., Betler, T., Bowsher, K., Brown, E. H. P., Clanton, S. T., Degenhart, A. D., Foldes, S. T., Gaunt, R. A., Gyulai, F. E., Harchick, E. A., Harrington, D., Helder, J. B., Hemmes, T., Johannes, M. S., Katyal, K. D., Ling, G. S. F., McMorland, A. J. C., Palko, K., Para, M. P., Scheuermann, J., Schwartz, A. B., Skidmore, E. R., Solzbacher, F., Srikameswaran, A. V., Swanson, D. P., Swetz, S., Tyler-Kabara, E. C., Velliste, M., Wang, W., Weber, D. J., Wodlinger, B. and Boninger, M. L. (2014), Collaborative Approach in the Development of High-Performance Brain–Computer Interfaces for a Neuroprosthetic Arm: Translation from Animal Models to Human Control. Clinical and Translational Science, 7: 52–59. doi: 10.1111/cts.12086
- Issue published online: 14 FEB 2014
- Article first published online: 27 AUG 2013
- Defense Advanced Research Projects Agency (DARPA) Revolutionizing Prosthetics. Grant Number: N66001-10-C-4056
- National Institutes of Health (NIH). Grant Number: 8KL2TR000146-07
- Office of Research and Development, Rehabilitation Research & Development Service
- Department of Veterans Affairs. Grant Numbers: # B6789C, B7143R, RX720
- UPMC Rehabilitation Institute
- clinical trials;
- translational research
Our research group recently demonstrated that a person with tetraplegia could use a brain–computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations.