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Carcinoma cuniculatum: not a verrucous carcinoma

Authors


Melanie J. Kubik, MD

Department of Pathology and Laboratory

Medicine,

University of Florida College of

Medicine-Jacksonville,

655 West 8th Street,

Box C-504,

Jacksonville, FL 32209, USA

Tel.: +1 904 244 5517

fax: +1 904 244 8286

e-mail: melanie.kubik@jax.ufl.edu

Abstract

Background

Carcinoma cuniculatum and verrucous carcinoma are both very well differentiated forms of squamous carcinoma and thus difficult to separate histologically from pseudocarcinomatous hyperplasia. The diagnosis of each often requires clinical-pathologic correlation.

Methods

We reviewed the literature on cases reported as carcinoma cuniculatum and compared these to the cases originally reported by Aird et al. In addition, we report an additional case of this entity that we encountered in our practice.

Results

In reviewing the literature it is evident that most authors consider carcinoma cuniculatum and verrucous carcinoma to be synonymous even though Aird's original two cases had no verrucous features. The lack of a clear conceptual distinction between these two entities may cause diagnostic confusion.

Conclusion

The purpose of this report is to record a case of carcinoma cuniculatum which the authors believe to be similar to those reported by Aird et al., to emphasize the differences between carcinoma cuniculatum and verrucous carcinoma, and to explain how the lack of a clear conceptual distinction between these two tumors can lead to further delay in an already difficult diagnosis.

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