Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor


Antonio Cozzio, MD, PhD,

Department of Dermatology, University Hospital

of Zurich, Gloriastrasse 31, 8091 Zurich,


Tel: +41 44 255 34 71

Fax: +41 44 255 44 03

e-mail: cozzio@usz.ch


Primary cutaneous follicle center lymphoma (pcFCL) is an indolent type of primary cutaneous B-cell lymphoma (pcBCL) rarely disseminating to other organs. PcBCL with spindle-cell morphology has been described as a rare variant of pcFCL but the prognosis data of this variant is sparse.

We report a rare case of spindle-cell pcFCL with CD20+, CD79a+, CD3+, Bcl-6+, Mum-1 and CD10tumor cells that infiltrated the hepatic hilum, mimicking a Klatskin tumor.

On the basis of the sparse published data on spindle-cell morphology of pcBCL, this growth pattern should elicit awareness of an increased risk of systemic involvement in the otherwise indolent pcFCL.