‘Monster cell’ melanoma with pulmonary metastasis and cyclin D1 amplification
Article first published online: 11 OCT 2012
Copyright © 2012 John Wiley & Sons A/S
Journal of Cutaneous Pathology
Volume 40, Issue 1, pages 61–65, January 2013
How to Cite
‘Monster cell’ melanoma with pulmonary metastasis and cyclin D1 amplification., , , .
- Issue published online: 21 DEC 2012
- Article first published online: 11 OCT 2012
- Accepted manuscript online: 28 SEP 2012 11:57AM EST
- Manuscript Accepted: 23 AUG 2012
- Manuscript Revised: 17 JUL 2012
- Manuscript Received: 2 APR 2012
- cyclin d1;
- monster cells
Markedly pleomorphic epithelioid cells with high mitotic activity, giant cell formation, very large atypical nuclei, multiple nucleoli and abundant cytoplasm characterize ‘monster’ cells and may indicate aggressive tumor behavior. Very rare reports of melanomas comprised of ‘monster cells’ or cells with comparable histomorphological features, found in tissue samples from skin, lymph nodes, CNS, oral cavity and ileum have been published in the literature. This case is the first such description in the lung, and it is characterized with a battery of immunohistochemical stains; BRAF mutation status was negative, and fluorescence in situ hybridization analysis revealed increased copy number gains in 11q (cyclin D1), which is associated with poor prognosis in melanoma. The presence of monster cells in melanoma was associated with aggressive behavior in the reported patient.