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Primary signet-ring cell carcinoma of the axilla


Paul Bogner, MD,

Roswell Park Cancer institute, Elm and Carlton Streets, Buffalo, NY 14263, USA

Tel: +1 716 845 2300

Fax: +1 716 845 3427



Primary cutaneous histiocytoid or signet-ring cell carcinoma represents an extremely rare adnexal neoplasm that most frequently presents on the eyelid but more rarely may present in the axilla. As this tumor can resemble metastatic carcinoma with signet-ring cells, especially lobular carcinoma of the breast, it can often present a diagnostic challenge. We present a case of cutaneous signet-ring cell carcinoma presenting in the axilla and outline the challenges of diagnosing this rare malignancy.