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Congenital disseminated tufted angioma


Tianwen Gao, MD, PhD,

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 Changlexi Rd, Xian, China

Tel: +86 2984775401

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Tufted angioma represents a rare vascular tumor that can develop in children and young adults. It usually presents as solitary plaque or large tumor on the extremities, trunk or other anatomic sites. Histopathologically, it is characterized by proliferation of closely packed capillaries in the dermis in a ‘cannonball’ distribution. We described a 2-month-old child who developed widespread disseminated red papules since her birth. Eight lesions were excised for histopathology, seven of which showed typical cannonball-like distribution of proliferative capillaries, characteristic of tufted angioma, and one on the hand which showed focal disseminated proliferation of endothelial cells. Immunohistochemistry showed focal D2-40 positivity in one lesion and was negative in the other seven. Expression of Prox1 and Glut-1 was negative in all lesions. This case represented a disseminated form of tufted angioma.