Indolent course of cutaneous gamma-delta T-cell lymphoma
Article first published online: 4 FEB 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 40, Issue 10, pages 896–902, October 2013
How to Cite
Indolent course of cutaneous gamma-delta T-cell lymphoma., , , , .
- Issue published online: 17 SEP 2013
- Article first published online: 4 FEB 2013
- Manuscript Accepted: 16 DEC 2012
- Manuscript Revised: 3 DEC 2012
- Manuscript Received: 10 SEP 2012
- connective tissue disease panniculitis;
- gamma-delta T-cell lymphoma;
- panniculitic lymphoma
Cutaneous gamma-delta T-cell lymphoma (γδTCL) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57-year-old woman with a 3-year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma-delta T-cell infiltrate, leading to a diagnosis of cutaneous γδTCL. The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδTCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδTCL.