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Angiofibromas with multiple epidermoid cysts in tuberous sclerosis: new mutation or post-traumatic?

Authors


Xiang-chun Han

Department of Pathology, The First Affiliated Hospital to Hebei North University, Zhangjiakou 075000, China

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e-mail: hanxiangchun1976@163.com

Abstract

Tuberous sclerosis is a genetic multisystem disorder characterized by widespread hamartomas in several organs. Clinically, more than 90% of affected patients have skin lesions including facial angiofibromas, periungual fibromas, hypomelanotic macule, etc. Periungual fibroma is one of the major diagnostic criteria of tuberous sclerosis and has the same pathology (angiofibroma) as the facial papules. We herein describe an interesting histologic variant of angiofibromas coupled with multiple epidermoid cysts in a 33-year-old patient with tuberous sclerosis.

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