An immunohistochemical study of verrucous hemangiomas
Version of Record online: 11 APR 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Journal of Cutaneous Pathology
Volume 40, Issue 5, pages 472–476, May 2013
How to Cite
An immunohistochemical study of verrucous hemangiomas., , , , , , , , , .
- Issue online: 11 APR 2013
- Version of Record online: 11 APR 2013
- Accepted manuscript online: 23 FEB 2013 07:39AM EST
- Manuscript Accepted: 25 JAN 2013
- Manuscript Revised: 20 DEC 2012
- Manuscript Received: 25 OCT 2012
- vascular malformation;
- verrucous hemangioma;
According to the International Society for the study of vascular Anomalies, vascular anomalies are classified as vascular neoplasms and vascular malformations. In some vascular lesions, categorization as a neoplasm or malformation has not been established with confidence so far. In order to further clarify the nosology of verrucous hemangioma, we studied 13 cases.
To analyze immunohistochemical characteristics of verrucous hemangiomas in order to gain further insight in its histogenesis.
We carried out a retrospective review. Immunohistochemical expression for Wilms tumor 1 (WT1), Glut-1 and D2-40 was performed in 13 cases.
Immunohistochemistry performed with Glut-1 and WT1 showed positive staining in all lesions. All verrucous hemangiomas lacked D2-40 immunostaining.
This is the first report in the literature investigating WT1 in verrucous hemangioma in order to further clarify the nosology of this vascular anomaly. Despite the clinical features of verrucous hemangioma, which are similar to those seen in vascular malformations, verrucous hemangioma exhibited an immunoprofile similar to vascular neoplasms, according to WT1 and Glut-1 positivity.