Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma
Loren E. Clarke, MD,
Assistant Professor, Departments of Pathology & Dermatology, Penn State Hershey Medical Center, 500 University Drive H179, Hershey, PA 17033, USA.
Tel: +1 717 531 1669
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Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs.
We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD.
We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4.
We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.