Both authors have contributed equally to this work.
Levels of the EMT-related protein Snail/Slug are not correlated with p53/p63 in cutaneous squamouscell carcinoma
Article first published online: 23 MAR 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 40, Issue 7, pages 651–656, July 2013
How to Cite
Levels of the EMT-related protein Snail/Slug are not correlated with p53/p63 in cutaneous squamous cell carcinoma., , , , , , , , .
- Issue published online: 16 JUN 2013
- Article first published online: 23 MAR 2013
- Accepted manuscript online: 6 MAR 2013 02:56PM EST
- Manuscript Accepted: 10 APR 2011
- Manuscript Revised: 22 MAR 2011
- Manuscript Received: 16 OCT 2010
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Environment Research and Technology Development Fund of the Ministry of the Environment
- cutaneous squamous cell carcinoma;
The contribution of the E-cadherin transcriptional repressors Snail and Slug to invasion and metastasis has strengthened the evidence for the importance of epithelial-mesenchymal transition (EMT) in carcinoma progression. However, to the best of our knowledge, no study has described the immunohistochemical staining of the EMT-related proteins Snail/Slug in skin tumors and the correlation between Snail/Slug and tumor suppressor p53/p63.
We performed immunohistological staining of Snail, Slug, E-cadherin, p53 and p63 in 20 archived specimens each of seborrheic keratosis (SK), actinic keratosis (AK) and squamous cell carcinoma in situ (SCCIS), and 53 specimens of cutaneous squamous cell carcinomas (SCC). Fifteen normal skin (NS) specimens served as controls.
Significant negative correlations were observed between Snail and E-cadherin expression and between Slug and E-cadherin expression (Snail: R2 = 0.5432, p < 0.01; Slug: R2 = 0.4666, p < 0.01).
The staining intensities of Snail and Slug are associated with decreased E-cadherin staining in SCC and this may promote EMT. However, the staining intensities of p53 and p63 are not significantly correlated with the loss of E-cadherin.