Present address: Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature†
Article first published online: 8 MAY 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 40, Issue 8, pages 734–739, August 2013
How to Cite
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature†., , .
Presented as a poster at Symposium XXX of the International Society of Dermatopathology (ISDP) in Santiago, Chile; October 28–31, 2009.
- Issue published online: 17 JUL 2013
- Article first published online: 8 MAY 2013
- Accepted manuscript online: 15 APR 2013 12:47PM EST
- Manuscript Accepted: 21 JUL 2011
- Manuscript Revised: 18 JUL 2011
- Manuscript Received: 29 JAN 2011
- atypical features;
- cutaneous neoplasm;
- soft tissue tumors
Pleomorphic liposarcoma (PLPS) is a rare, high-grade sarcoma defined by the presence of pleomorphic lipoblasts. Constituting 5% of all liposarcomas, PLPS usually arises in deep soft tissues of the extremities, with rare occurrences in the dermis and subcutis. We describe a unique case of an 85-year-old Caucasian gentleman with a 1 year history of a pedunculated, pink, non-tender papule on the dorsum of his left arm, measuring 1.0 cm in maximum dimension. Biopsy revealed a dermal collection of atypical epithelioid and spindle cells superimposed on a sclerotic background, resembling a pleomorphic fibroma on low power. On high power, a central focus of discrete adipocytic differentiation with pleomorphic lipoblasts was present. Tumor cells were positive for S-100 and negative for desmin, actin, CD68, keratin, MART-1 and CD34. Clinicopathologic findings were consistent with PLPS and the diagnosis was made. PLPS is rarely localized to the dermis and one with low power features resembling a pleomorphic fibroma has not been previously described in the literature.