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Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases

Authors

  • Bruno Augusto Benevenuto de Andrade,

    Corresponding author
    • Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
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  • Felipe Paiva Fonseca,

    1. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
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  • Fábio Ramôa Pires,

    1. Oral Pathology, School of Dentistry, State University of Rio de Janeiro, Rio de Janeiro, Brazil
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  • Ana Terezinha Marques Mesquita,

    1. Department of Dentistry, College of Basic Sciences and Health, Federal University of Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil
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  • Saulo Gabriel Moreira Falci,

    1. Department of Dentistry, College of Basic Sciences and Health, Federal University of Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil
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  • Alan Roger dos Santos Silva,

    1. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
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  • Pablo Agustin Vargas,

    1. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
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  • Jacks Jorge,

    1. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
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  • Oslei Paes de Almeida

    1. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
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Bruno Augusto Benevenuto de Andrade

Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Avenue Limeira 901, P.O. Box 52, 13414-903, Piracicaba, São Paulo, Brazil

Tel: +5519 21065315

Fax: +5519 21065218

e-mail: augustodelima33@hotmail.com

Abstract

Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well-tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.

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