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Benign lymphangioendothelioma: a clinical, histopathologic and immunohistochemical analysis of four cases

Authors

  • Lei Wang,

    1. Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xian, China
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  • Liuqing Chen,

    1. Department of Dermatology, Wuhan No.1 Hospital, Wuhan, China
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  • Xichuan Yang,

    1. Department of Dermatology, Xinan Hospital, The Third Military Medical University, Chongqing, China
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  • Tianwen Gao,

    Corresponding author
    1. Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xian, China
    • Gang Wang, MD, PhD,

      Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, No. 15 of Changlexi Road, Xian 710032, China

      e-mail: xjwgang@fmmu.edu.cn

      or

      Tianwen Gao, MD, PhD,

      Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, No. 15 of Changlexi Road, Xian 710032, China

      Tel/Fax: 862984775401

      e-mail: gaotw@fmmu.edu.cn

    Search for more papers by this author
  • Gang Wang

    Corresponding author
    1. Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xian, China
    • Gang Wang, MD, PhD,

      Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, No. 15 of Changlexi Road, Xian 710032, China

      e-mail: xjwgang@fmmu.edu.cn

      or

      Tianwen Gao, MD, PhD,

      Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, No. 15 of Changlexi Road, Xian 710032, China

      Tel/Fax: 862984775401

      e-mail: gaotw@fmmu.edu.cn

    Search for more papers by this author

Abstract

Background

Benign lymphangioendothelioma represents a rare lymphatic vascular proliferation characterized by proliferation of irregular and thin-walled vessels dissecting amongst dermal collagen. Immunohistochemical analysis has been lacking in most previously reported cases.

Methods

Herein, we report the clinical and histopathologic characteristics of four cases of benign lymphangioendothelioma. Immunohistochemical study was completed for all lesions.

Results

All lesions presented as large, red to brown patches or plaques. Three lesions were located on the thigh and one lesion was located on the neck. Histopathologically, all lesions showed proliferation of anastomotic or retiform thin-walled vessels with a single layer of endothelial cells that dissect the dermis. D2-40 and Prox1 immunostains were positive and Wilms tumor 1 (WT-1) immunostain was negative in all cases.

Conclusion

Benign lymphangioendothelioma represents a lymphatic vascular proliferation. A lack of expression of WT-1 suggests it represents a lymphatic vascular malformation.

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