Panfollicular carcinoma or trichoblastic carcinoma with panfollicular differentiation?
Version of Record online: 16 OCT 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 40, Issue 11, pages 976–981, November 2013
How to Cite
Panfollicular carcinoma or trichoblastic carcinoma with panfollicular differentiation?, , , , , , .
- Issue online: 16 OCT 2013
- Version of Record online: 16 OCT 2013
- Accepted manuscript online: 27 AUG 2013 09:30AM EST
- Manuscript Accepted: 19 JUL 2013
- Manuscript Revised: 28 MAY 2013
- Manuscript Received: 11 SEP 2012
- cutaneous neoplasm;
- hair follicle
Herein, we report two cases of a follicular neoplasm with panfollicular differentiation showing architectural and cytologic findings suggestive of a malignancy. Immunohistochemical analysis of β-catenin expression in the neoplasm showed nuclear and cytoplasmic immunoreactivity, with no reactivity in the transitional and shadow cells, consistent with β-catenin expression of pilomatrical tumors. Staining for BerEp4 was positive at the periphery of both neoplasms, suggesting germinative differentiation of the neoplastic cells, whereas staining for the follicular stem-cell marker PHLDA-1 (TDAG51) showed strong focal expression in the tumor cells of both cases. Given these findings, these neoplasms show features of both panfollicular neoplasms and basal cell carcinoma with panfollicular/matrical differentiation. These are the first cases of this neoplasm reported to date. More reports are needed to assess their malignant potential.