Giant cell angiofibroma or localized periorbital lymphedema?
Article first published online: 3 OCT 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 40, Issue 12, pages 1059–1062, December 2013
How to Cite
Giant cell angiofibroma or localized periorbital lymphedema?, , , , .
- Issue published online: 26 NOV 2013
- Article first published online: 3 OCT 2013
- Accepted manuscript online: 4 SEP 2013 12:58PM EST
- Manuscript Received: 25 AUG 2013
- Manuscript Revised: 24 AUG 2013
- Manuscript Accepted: 24 AUG 2013
- giant cell angiofibroma;
- herniated orbital fat;
- massive localized lymphedema
Giant cell angiofibroma represents a rare soft tissue neoplasm with a predilection for the orbit. We recently encountered a mass removed from the lower eyelid of a 56-year-old female that histopathologically resembled giant cell angiofibroma. The process consisted of haphazardly arranged CD34-positive spindled and multinucleated cells within an edematous, densely vascular stroma. However, the patient had recently undergone laryngectomy and radiotherapy for a laryngeal squamous cell carcinoma. A similar mass had arisen on the contralateral eyelid, and both had developed several months post-therapy. Lymphedema of the orbit can present as tumor-like nodules and in some cases may share histopathologic features purported to be characteristic of giant cell angiofibroma. A relationship between giant cell angiofibroma and lymphedema has not been established, but our case suggests there may be one. The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis.