Double-positive CD4/CD8 mycosis fungoides: a rarely reported immunohistochemical profile
Version of Record online: 20 NOV 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 41, Issue 1, pages 58–62, January 2014
How to Cite
Double-positive CD4/CD8 mycosis fungoides: a rarely reported immunohistochemical profile., , , , , , .
- Issue online: 16 DEC 2013
- Version of Record online: 20 NOV 2013
- Accepted manuscript online: 17 OCT 2013 08:55AM EST
- Manuscript Accepted: 10 OCT 2013
- mycosis fungoides;
- confocal microscopy;
- T-cell phenotype
Mycosis fungoides (MF) represents the most common epidermotropic cutaneous T-cell lymphoma (CTCL), and tumor cells typically express a mature T-helper memory phenotype. A minority of MF patients display an unusual phenotype, which may be either CD4(−)/CD8(+) or double negative. Herein, we report a case of biopsy-proven MF in a 31-year-old woman who presented with infiltrated plaques involving photoprotected areas of the skin. Immunohistochemical study combined with confocal microscopy revealed co-expression of CD4 and CD8 in a subset of atypical T lymphocytes. To our knowledge, this is the second report of a CD4/CD8 dual-positive MF.