Transepithelial elimination in sarcoidosis: a frequent finding
Article first published online: 20 NOV 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 41, Issue 1, pages 22–27, January 2014
How to Cite
Transepithelial elimination in sarcoidosis: a frequent finding., , .
- Issue published online: 16 DEC 2013
- Article first published online: 20 NOV 2013
- Accepted manuscript online: 23 OCT 2013 04:03PM EST
- Manuscript Accepted: 15 OCT 2013
- Manuscript Revised: 5 OCT 2013
- Manuscript Received: 7 JUN 2013
- transepithelial elimination;
Transepithelial elimination is a process by which dermal materials are expelled through an active epithelial-dermal connective tissue interaction. It has been described as a regular or sporadic occurrence in a variety of dermatologic conditions, including sarcoidosis.
Our patient demonstrated a rare presentation of sarcoidosis involving the genital region, with histopathologic evidence of transepithelial elimination of granulomas. This prompted us to conduct the first case series documenting the frequency of transepithelial elimination in sarcoidosis.
Slides of skin biopsies from patients (n = 50) with cutaneous sarcoidosis from the University of Alabama at Birmingham were evaluated for transepithelial elimination. Transepithelial elimination was defined as epithelial channel formation with a sarcoidal-type granuloma completely surrounded by squamous epithelium on the section examined.
Transepithelial elimination was found in 9 of 50 cases (18%).
This is the first report of transepithelial elimination in a lesion of sarcoidosis localized to the vulvar area, and one of only six reports in the English literature documenting cutaneous sarcoidosis with histopathologic evidence of transepithelial elimination. These reports are reviewed herein. Surprisingly, the results from this case series indicate that transepithelial elimination is more common in cutaneous sarcoidosis than one may surmise from the current literature.