Epidermal dynamics and patterns of intraepidermal melanoma
Article first published online: 21 JAN 2014
Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
Journal of Cutaneous Pathology
Volume 41, Issue 3, pages 297–302, March 2014
How to Cite
Epidermal dynamics and patterns of intraepidermal melanoma..
- Issue published online: 23 FEB 2014
- Article first published online: 21 JAN 2014
- Accepted manuscript online: 16 DEC 2013 10:38AM EST
- Manuscript Accepted: 20 OCT 2013
- Manuscript Revised: 14 SEP 2013
- Manuscript Received: 27 JUL 2013
- epidermal dynamics;
Dermatopathologists know that the epidermis represents a dynamic compartment and that its cells mature from the basal layer to the skin surface in approximately 45 days. What may seem intuitive – but not obvious – is that the dynamics of the epidermis can affect the patterns of melanoma cells within the epidermis. Here this conjecture is explored with an abstract, theoretical model.
To control the independent effects of epidermal replacement velocity and thickness as well as rate of melanoma cell penetration of the epidermis, an abstraction of the epidermis was created and simulated via computer.
Simulated plots of the epidermis show that the number and pattern of melanoma cells in the epidermis is affected by the probability of melanoma cells entering the epidermis, by the velocity of epidermal replacement and by epidermal thickness.
This analysis suggests that the dynamics of the epidermis are sufficient to affect the patterns of melanoma cells within the epidermis.