Pulse granuloma of the lip: morphologic clues in its differential diagnosis


  • Angel Fernandez-Flores,

    Corresponding author
    1. Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain,
    • Angel Fernandez-Flores, MD, PhD

      Servicio de Anatomía Patologica, Hospital El Bierzo, Medicos sin Frontreas 7, Ponferrada 24411, Spain

      Tel: +34 987 45 42 00

      Fax: (0034) 987412540

      e-mail: dermatopathonline@gmail.com

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  • Marcela Saeb-Lima

    1. Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INER/CIENI, Hospital Angeles Lomas, Centro Medico ABC, Mexico City, Mexico
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Pulse granuloma is not a common condition in cutaneous pathology. In diagnosing this condition, it is essential to determine if the foreign fragmented bodies are really vegetable parts. Certain vegetable structures, such as hyaline rings, have been clearly emphasized in the literature. However, other vegetable parts can show certain morphologic similarities with animal structures, especially if observed in a fragmented biopsy, as is the case with the pericarp (which can mimic the cuticle of a maggot) or the endosperm (which can mimic the fat cells of the larva). Herein, we present a case of pulse granuloma involving the lip, an uncommon location for this condition. We also describe the histopathologic appearance of experimentally obtained maggots and pupae, as well as that of several vegetable seeds. We compare some of the vegetable and animal structures and emphasize the differential diagnosis between them.