Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review
Article first published online: 13 FEB 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 41, Issue 4, pages 370–379, April 2014
How to Cite
Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review., , .
- Issue published online: 21 MAR 2014
- Article first published online: 13 FEB 2014
- Accepted manuscript online: 22 JAN 2014 01:11AM EST
- Manuscript Accepted: 12 JAN 2014
- Manuscript Received: 1 JAN 2014
- nodular syphilis;
- secondary syphilis;
A 62-year-old male presented with a 10-day history of a diffuse, erythematous papular rash sparing the palms and soles. Histopathologic examination of a skin lesion showed loose non-caseating granulomas in a lymphoplasmacytic background. Scattered spirochetes were identified by Treponema pallidum immunohistochemistry, in keeping with a diagnosis of secondary syphilis. Granulomatous inflammation in secondary syphilis is uncommon. A review of the literature reveals that the majority of prior reported cases of granulomatous secondary syphilis share similar characteristics to this case; namely, a papular or nodular clinical presentation, sparing of the palms and soles, and collections of epithelioid histiocytes with associated lymphocytes and variable numbers of plasma cells.