Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma
Article first published online: 7 MAR 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 41, Issue 5, pages 447–450, May 2014
How to Cite
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma., , .
- Issue published online: 24 APR 2014
- Article first published online: 7 MAR 2014
- Accepted manuscript online: 10 FEB 2014 05:20PM EST
- Manuscript Accepted: 28 JAN 2014
- Manuscript Revised: 12 DEC 2013
- Manuscript Received: 15 AUG 2013
- spindle cell hemangioma;
- Wilms tumor 1 (WT1)
Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.
We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).
The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.
Our results suggest that spindle cell hemangioma is a lymphatic malformation.