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Keywords:

  • D2-40;
  • lymphatic;
  • Prox1;
  • spindle cell hemangioma;
  • Wilms tumor 1 (WT1)

Background

Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.

Methods

We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).

Results

The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.

Conclusion

Our results suggest that spindle cell hemangioma is a lymphatic malformation.