Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma

Authors

  • Lei Wang,

    1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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  • Tianwen Gao,

    Corresponding author
    1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
    • Prof. Gang Wang, MD, PhD

      Prof. Tianwen Gao, MD, PhD

      Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127, Changlexi Rd, Xian 710032, China

      Tel/Fax: +86 2984775401

      e-mails: xjwgang@fmmu.edu.cn; gaotw@fmmu.edu.cn

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  • Gang Wang

    Corresponding author
    1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
    • Prof. Gang Wang, MD, PhD

      Prof. Tianwen Gao, MD, PhD

      Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127, Changlexi Rd, Xian 710032, China

      Tel/Fax: +86 2984775401

      e-mails: xjwgang@fmmu.edu.cn; gaotw@fmmu.edu.cn

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Abstract

Background

Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.

Methods

We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).

Results

The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.

Conclusion

Our results suggest that spindle cell hemangioma is a lymphatic malformation.

Ancillary