Cutaneous lymphatic malformation characterized by swelling of digits: a report of six cases
Article first published online: 7 MAR 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Journal of Cutaneous Pathology
Volume 41, Issue 5, pages 451–456, May 2014
How to Cite
Cutaneous lymphatic malformation characterized by swelling of digits: a report of six cases., , .
- Issue published online: 24 APR 2014
- Article first published online: 7 MAR 2014
- Accepted manuscript online: 12 FEB 2014 05:37AM EST
- Manuscript Accepted: 8 FEB 2014
- Manuscript Revised: 29 JAN 2014
- Manuscript Received: 24 DEC 2013
- vascular proliferation;
Cutaneous lymphatic malformations represent a group of heterogeneous diseases. In clinical practice, some cases of cutaneous lymphatic malformation have been found to differ from the well-characterized entities, and are difficult to classify.
To report the clinical, histopathological and immunohistochemical characteristics of six cases of lymphatic malformation characterized by swelling of the digits.
Six patients with swelling of the digits were included in this study. Histopathological examination and immunohistochemical staining of CD31, D2-40, Prox1, Wilms tumor 1 (WT-1) and human herpesvirus-8 (HHV-8) were performed for all cases.
All cases were congenital lesions and presented as swelling of single or multiple digits. Histopathologically, the lesions showed proliferation of small-to-medium-sized vessels in the dermis and subcutaneous tissue. These abnormal vessels were positive for CD31, D2-40 and Prox1, and negative for WT-1 and HHV-8.
The six cases reported herein represent a specific cutaneous lymphatic malformation different from previously reported entities.