The Auckland keratoconus study: Identifying predictors of acute corneal hydrops in keratoconus
Article first published online: 21 FEB 2013
© 2013 The Authors. Clinical and Experimental Optometry © 2013 Optometrists Association Australia
Clinical and Experimental Optometry
Special Keratoconus issue co-ordinated by Richard Lindsay
Volume 96, Issue 2, pages 208–213, March 2013
How to Cite
Fan Gaskin, J. C., Good, W. R., Jordan, C. A., Patel, D. V. and McGhee, C. N. (2013), The Auckland keratoconus study: Identifying predictors of acute corneal hydrops in keratoconus. Clinical and Experimental Optometry, 96: 208–213. doi: 10.1111/cxo.12048
- Issue published online: 18 MAR 2013
- Article first published online: 21 FEB 2013
- Manuscript Accepted: 17 JAN 2013
- Manuscript Revised: 13 JAN 2013
- Manuscript Received: 4 DEC 2012
- corneal hydrops;
- New Zealand
The aim was to identify potential factors associated with acute corneal hydrops in a New Zealand population with keratoconus referred to a hospital eye service.
In a single hospital centre, in a retrospective review, demographic and clinical features of subjects with keratoconus and corneal hydrops over a 17-year period were compared with an age- and gender-matched control group of subjects with keratoconus but no history of corneal hydrops.
One hundred and one eyes of 101 subjects (mean age 24.6 ± 8.4 years) were identified with keratoconus-related corneal hydrops. Subjects were more likely to be of Pacific but less likely to be of New Zealand European ethnicity than control subjects (n = 101). In comparison, Maori ethnicity was not found to have a significantly positive or negative association with hydrops. The pre-hydrops visual acuity (VA) of affected eyes was poorer than that of controls (p < 0.001) at first presentation to our tertiary referral corneal and contact lens service. Hydrops typically developed approximately four years after diagnosis of keratoconus. Subjects with hydrops were more likely to have a history of eye-rubbing (p = 0.011) but less likely to have a family history of keratoconus (p = 0.05). In 31 cases, the acute hydrops event was their first optometric/ophthalmologic contact. There were no statistically significant differences in the prevalence of atopic disease, contact lens wear or overall corneal transplantation rate between the two groups.
Pacific ethnicity, history of eye-rubbing, poor VA at first hospital presentation and lack of family history were statistically associated with developing acute corneal hydrops in keratoconus in a New Zealand population. Greater understanding of such predisposing risk factors may help develop early management strategies to delay or prevent progression of this disease.