Bethany White MPH, PhD candidate, Annie Madden BA (hons), Margaret Hellard MBBS, PhD, Professor, Thomas Kerr PhD, Associate Professor, Maria Prins PhD, Professor, Kimberly Page PhD, MPH, Professor, Gregory J. Dore MBBS, PhD, Professor, Lisa Maher PhD, Professor.
Increased hepatitis C virus vaccine clinical trial literacy following a brief intervention among people who inject drugs
Article first published online: 1 NOV 2012
© 2012 Australasian Professional Society on Alcohol and other Drugs
Drug and Alcohol Review
Volume 32, Issue 4, pages 419–425, July 2013
How to Cite
White, B., Madden, A., Hellard, M., Kerr, T., Prins, M., Page, K., Dore, G. J. and Maher, L. (2013), Increased hepatitis C virus vaccine clinical trial literacy following a brief intervention among people who inject drugs. Drug and Alcohol Review, 32: 419–425. doi: 10.1111/dar.12000
- Issue published online: 2 JUL 2013
- Article first published online: 1 NOV 2012
- Manuscript Accepted: 20 SEP 2012
- Manuscript Received: 10 JUL 2012
- University of New South Wales (The UNSW Hepatitis C Vaccine Initiative)
- National Health and Medical Research Council. Grant Number: #630483
- National Health and Medical Research Council Senior Research Fellowships
- NHMRC Practitioner Fellowship
- Michael Smith Foundation for Health Research
- Canadian Institutes for Health Research
- US National Institutes for Health (NIH). Grant Numbers: 2 R01 DA016017-03A1, 5 U19 AI40034-13
- hepatitis C virus;
- injecting drug use;
- clinical trial literacy;
- brief intervention;
- vaccine preparedness study
Introduction and Aims
While people who inject drugs are at high risk of hepatitis C virus (HCV) infection and will be the target population for future HCV vaccine trials, little is known about clinical trial literacy (CTL) in this group. We assessed the impact of a brief intervention (BI) designed to improve HCV vaccine CTL among people who inject drugs in Sydney, Australia.
Design and Methods
People who inject drugs enrolled in a community-based prospective observational study between November 2008 and September 2010 (n = 102) completed a CTL assessment followed immediately by the BI. Post-test assessment was conducted at 24 weeks.
The median age of the sample was 27 years, 73% were male and 60% had 10 or less years of schooling. The median time since first injection was 5 years and 20% reported daily or more frequent injecting. The mean number of correct responses increased from 5.3 to 6.3/10 (t = −4.2; 101df, P < 0.001) 24 weeks post-intervention. Statistically significant differences were observed for three knowledge items with higher proportions of participants correctly answering questions related to randomisation (P = 0.002), blinding (P = 0.005) and vaccine-induced seropositivity (P = 0.003) post-intervention.
Discussion and Conclusions
A significant increase in HCV vaccine CTL was observed, suggesting that new and relatively novel concepts can be learned and recalled in this group. These findings support the feasibility of future trials among this population. [Correction added on 21 November 2012, after first online publication: T-score for mean number of correct responses was corrected to ‘−4.2’ in the Results section.] [White B, Madden A, Hellard H, Kerr T, Prins M, Page K, Dore GJ, Maher L. Increased hepatitis C virus vaccine clinical trial literacy following a brief intervention among people who inject drugs. Drug Alcohol Rev 2013;32:419–425]