Increased hepatitis C virus vaccine clinical trial literacy following a brief intervention among people who inject drugs

Authors

  • Bethany White,

    Corresponding author
    1. School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia
    • Viral Hepatitis Epidemiology and Prevention Program, The Kirby Institute, University of New South Wales, Sydney, Australia
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  • Annie Madden,

    1. Australian Injecting & Illicit Drug Users League, Canberra, Australia
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  • Margaret Hellard,

    1. Centre for Population Health, The Macfarlane Burnet Institute for Medical Research, Melbourne, Australia
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  • Thomas Kerr,

    1. Urban Health Research Initiative, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada
    2. Division of AIDS, Department of Medicine, University of British Columbia, Vancouver, Canada
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  • Maria Prins,

    1. Academic Medical Centre, Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, the Netherlands
    2. Cluster of Infectious Diseases, Department of Research, Public Health Service, Amsterdam, the Netherlands
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  • Kimberly Page,

    1. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA
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  • Gregory J. Dore,

    1. Viral Hepatitis Clinical Research Program, The Kirby Institute, University of New South Wales, Sydney, Australia
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  • Lisa Maher

    1. Viral Hepatitis Epidemiology and Prevention Program, The Kirby Institute, University of New South Wales, Sydney, Australia
    2. School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia
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  • Bethany White MPH, PhD candidate, Annie Madden BA (hons), Margaret Hellard MBBS, PhD, Professor, Thomas Kerr PhD, Associate Professor, Maria Prins PhD, Professor, Kimberly Page PhD, MPH, Professor, Gregory J. Dore MBBS, PhD, Professor, Lisa Maher PhD, Professor.

Correspondence to Professor Lisa Maher, Viral Hepatitis Epidemiology and Prevention Program, The Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia. Tel: +61 2 9385 0900; Fax: +61 2 9385 1920; E-mail: lmaher@kirby.unsw.edu.au

Abstract

Introduction and Aims

While people who inject drugs are at high risk of hepatitis C virus (HCV) infection and will be the target population for future HCV vaccine trials, little is known about clinical trial literacy (CTL) in this group. We assessed the impact of a brief intervention (BI) designed to improve HCV vaccine CTL among people who inject drugs in Sydney, Australia.

Design and Methods

People who inject drugs enrolled in a community-based prospective observational study between November 2008 and September 2010 (n= 102) completed a CTL assessment followed immediately by the BI. Post-test assessment was conducted at 24 weeks.

Results

The median age of the sample was 27 years, 73% were male and 60% had 10 or less years of schooling. The median time since first injection was 5 years and 20% reported daily or more frequent injecting. The mean number of correct responses increased from 5.3 to 6.3/10 (t= −4.2; 101df, P< 0.001) 24 weeks post-intervention. Statistically significant differences were observed for three knowledge items with higher proportions of participants correctly answering questions related to randomisation (P= 0.002), blinding (P= 0.005) and vaccine-induced seropositivity (P= 0.003) post-intervention.

Discussion and Conclusions

A significant increase in HCV vaccine CTL was observed, suggesting that new and relatively novel concepts can be learned and recalled in this group. These findings support the feasibility of future trials among this population. [Correction added on 21 November 2012, after first online publication: T-score for mean number of correct responses was corrected to ‘−4.2’ in the Results section.] [White B, Madden A, Hellard H, Kerr T, Prins M, Page K, Dore GJ, Maher L. Increased hepatitis C virus vaccine clinical trial literacy following a brief intervention among people who inject drugs. Drug Alcohol Rev 2013;32:419–425]

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