Conflict of interest Ehrhardt Proksch and Regina Fölster-Holst have held lectures for Astellas Pharma GmbH. This study was supported by Astellas Pharma GmbH. Kersten Walter is an employee of Astellas Pharma GmbH.
Comparison of effects of tacrolimus ointment and mometasone furoate cream on the epidermal barrier of patients with atopic dermatitis
Article first published online: 2 APR 2013
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Volume 11, Issue 5, pages 437–443, May 2013
How to Cite
Dähnhardt-Pfeiffer, S., Dähnhardt, D., Buchner, M., Walter, K., Proksch, E. and Fölster-Holst, R. (2013), Comparison of effects of tacrolimus ointment and mometasone furoate cream on the epidermal barrier of patients with atopic dermatitis. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 11: 437–443. doi: 10.1111/ddg.12074
- Issue published online: 29 APR 2013
- Article first published online: 2 APR 2013
- Manuscript Accepted: 5 FEB 2013
- Manuscript Received: 12 NOV 2012
The skin barrier plays a crucial role in the pathophysiology of atopic dermatitis. The quality of the skin barrier can be assessed using a new semi-quantitative method to measure intercellular lipid lamellae. This procedure was used to evaluate the influence of the topical application of the calcineurin inhibitor tacrolimus 0.1% ointment (Protopic®) versus mometasone furoate cream (Ecural®) on the quality of the skin barrier.
Patients and Methods
20 adult patients with active atopic dermatitis (SCORAD 10–63) were included in an open, non-interventional study. Lesions on their forearms were treated twice daily over 10 days with either tacrolimus 0.1% ointment or mometasone furoate cream. At the beginning and the end of the treatment period, SCORAD, TEWL and skin hydration were determined and the intercellular lipids were measured using transmission electron microscopy.
The SCORAD improved in both groups nearly to the same extent, whereas TEWL and skin hydration improved significantly only in the tacrolimus group. Using the semi-quantitative analysis of intercellular lipid length per 1,000 nm2 intercellular space, a twofold increase for mometasone furoate cream and a fourfold increase for tacrolimus 0.1% ointment were determined.
In addition to its known antiinflammatory effect, tacrolimus 0.1% ointment leads also to a measurable increase of the lipids of the skin barrier in patients with atopic dermatitis, exceeding the effect of mometasone furoate cream.