Conflict of interest None.
Cutaneous and systemic plasmocytosis
Version of Record online: 12 AUG 2013
© The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Volume 11, Issue 12, pages 1161–1167, December 2013
How to Cite
Wagner, G., Rose, C., Klapper, W. and Sachse, M. M. (2013), Cutaneous and systemic plasmocytosis. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 11: 1161–1167. doi: 10.1111/ddg.12190
- Issue online: 24 NOV 2013
- Version of Record online: 12 AUG 2013
- Manuscript Accepted: 3 JUL 2013
- Manuscript Received: 4 JUN 2013
Cutaneous and systemic plasmacytosis is a rare disorder observed mainly in Japanese that features an infiltration of mature plasma cells in various organ systems. In addition to the skin, lymph nodes and bone marrow are regularly affected. Laboratory tests show a polyclonal hypergammaglobulinemia. The cutaneous morphology is characterized by red to dark brown macules, papules and plaques a few centimeters in diameter, usually distributed symmetrically on the face, neck and back. Etiology and pathogenesis are not known. It is speculated that a reactive dysfunction of plasma cells may be triggered by various stimuli, such as interleukin 6. Treatment of cutaneous and systemic plasmacytosis is difficult. A standardized treatment concept does not yet exist. Topical corticosteroids and calcineurin inhibitors are mainly used.