Multiple roles of Equarin during lens development

Authors

  • Xiaohong Song,

    1. Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
    Current affiliation:
    1. Department of Anatomy, Hokkaido University Graduate School of Medical Science, Sapporo, Japan
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  • Hideaki Tanaka,

    1. Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
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  • Kunimasa Ohta

    Corresponding author
    1. Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
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Abstract

Since the days of Hans Spemann, the ocular lens has served as one of the most important developmental systems for elucidating the fundamental processes of induction and differentiation. Lens is an important source of signals that influence the eye development and a variety of genes expressed by the lens have been identified. The identification of additional molecule(s), especially secreted ones that might mediate signals, will extend our knowledge of the molecular mechanisms of eye and lens development. Here, we will introduce a soluble molecule, Equarin, and discuss its vital role in multiple aspects of lens development.

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