Development, Growth & Differentiation

Cover image for Vol. 59 Issue 8

October 2017

Volume 59, Issue 8

Pages 627–673

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Articles
    1. You have free access to this content
      Issue Information (pages 627–628)

      Version of Record online: 15 OCT 2017 | DOI: 10.1111/dgd.12318

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      Cover Photograph: Actual allelic paring of Oct4 loci (Green). Oct4 loci frequently localize in close proximity to one another during the early stage of cellular differentiation of ESCs. In this issue, Asaka et al. (pp. 639–647) demonstrate a strict link of this phenomenon to pluripotent property with the comparison between ESCs and embryonal carcinoma cells.

  2. Original Articles

    1. Top of page
    2. Issue Information
    3. Original Articles
    1. BMP signaling regulates the skeletal and connective tissue differentiation during caudal fin regeneration in sailfin molly (Poecilia latipinna) (pages 629–638)

      Shailja Rajaram, Sonam Patel, Gowri Kumari Uggini, Isha Desai and Suresh Balakrishnan

      Version of Record online: 12 SEP 2017 | DOI: 10.1111/dgd.12392

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      In this study, we investigated the effects of BMP inhibition by LDN193189 on skeletal and connective tissues formation, at 5 days post amputation in the caudal fin of Poecilia latipinna. We observed that BMP inhibition leads to compromised growth of fin regenerate. Histological analysis supports the findings, as stunted progression of skeletal elements and below par formation of collagen. Biochemical analysis of collagen and subsequent transcript level analysis of genes that regulate the formation of skeletal elements reaffirm these observations. Overall, our results highlight the significance of BMP signaling in directing the blastemal cells for proper skeletal and connective tissue differentiation during caudal fin regeneration.

    2. Link between embryonic stem cell pluripotency and homologous allelic pairing of Oct4 loci (pages 639–647)

      Masamitsu N. Asaka, Kousuke Uranishi, Ayumu Suzuki, Masataka Hirasaki, Masazumi Nishimoto and Akihiko Okuda

      Version of Record online: 2 OCT 2017 | DOI: 10.1111/dgd.12403

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      Figure 5A shows transient homologous pairing of Oct4 alleles, but not Fshr alleles, of chromosome 17 in differentiation-induced mouse embryonic stem cells.

    3. You have full text access to this OnlineOpen article
      Microtubule array observed in the posterior-vegetal cortex during cytoplasmic and cortical reorganization of the ascidian egg (pages 648–656)

      Hirokazu Ishii, Toshiyuki Goto and Takahito Nishikata

      Version of Record online: 2 OCT 2017 | DOI: 10.1111/dgd.12405

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      We invented a new reagent that improves the immunostaining and successfully visualized a parallel array of thick microtubules in the posterior-vegetal cortex of fertilized ascidian eggs. Our results suggest that the microtubule array is important for cytoplasmic and cortical reorganization and anteroposterior axis formation.

    4. Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions (pages 657–673)

      Marissa Blume, Fuduki Inoguchi, Taku Sugiyama, Yuji Owada, Noriko Osumi, Yoshinari Aimi, Kosuke Taki and Yu Katsuyama

      Version of Record online: 25 SEP 2017 | DOI: 10.1111/dgd.12393

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      By detailed observations of developmental process of the hippocampal formation in Dab1 deficient mice, it was found that morphogenesis in the CA1, CA3, and dentate gyrus in the mutant was differently affected by Dab1 deficiency, suggesting that Dab1 is involved in these hipocampla subdivisions collaborating with different developmental mechanisms.

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