• 1
    Kaatsch P. Epidemiology of childhood cancer. Cancer Treat Rev2010; 36: 27785.
  • 2
    Mariotto AB, Rowland JH, Yabroff KR, et al.Long-term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev2009; 18: 103340.
  • 3
    Ries LAG, Melbert D, Krapcho M, et al.SEER Cancer Statistics Review, 1975–2005. Bethesda, MD: National Cancer Institute, 2008.
  • 4
    Butler RW, Mulhern RK. Neurocognitive interventions for children and adolescents surviving cancer. J Pediatr Psychol2005; 30: 6578.
  • 5
    Duffner PK. Risk factors for cognitive decline in children treated for brain tumors. Eur J Paediatr Neurol2010; 14: 10615.
  • 6
    Bhat SR, Goodwin TL, Burwinkle TM, et al.Profile of daily life in children with brain tumors: an assessment of health-related quality of life. J Clin Oncol2005; 23: 5493500.
  • 7
    Koch SV, Kejs AM, Engholm G, Johansen C, Schmiegelow K. Educational attainment among survivors of childhood cancer: a population-based cohort study in Denmark. Br J Cancer2004; 91: 9238.
  • 8
    Zebrack BJ, Gurney JG, Oeffinger K, et al.Psychological outcomes in long-term survivors of childhood brain cancer: a report from the childhood cancer survivor study. J Clin Oncol2004; 22: 9991006.
  • 9
    Grill J, Renaux VK, Bulteau C, et al.Long-term intellectual outcome in children with posterior fossa tumors according to radiation doses and volumes. Int J Radiat Oncol Biol Phys1999; 45: 13745.
  • 10
    Conklin HM, Li C, Xiong X, Ogg RJ, Merchant TE. Predicting change in academic abilities after conformal radiation therapy for localized ependymoma. J Clin Oncol2008; 26: 396570.
  • 11
    Rutkowski S, Bode U, Deinlein F, et al.Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med2005; 352: 97886.
  • 12
    Patel SK, Mullins WA, O’Neil SH, Wilson K. Neuropsychological differences between survivors of supratentorial and infratentorial brain tumours. J Intellect Disabil Res2011; 55: 3040.
  • 13
    Ris MD, Packer R, Goldwein J, Jones-Wallace D, Boyett JM. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children’s Cancer Group study. J Clin Oncol2001; 19: 34706.
  • 14
    Palmer SL, Goloubeva O, Reddick WE, et al.Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. J Clin Oncol2001; 19: 23028.
  • 15
    Conners CK. Conners’ Continuous Performance Test (CPT). Toronto, Canada: Multi-Health Systems, 1995.
  • 16
    Conners CK. Conners’ Continuous Performance Test (CPT II). New York: Multi-Health System, 2002.
  • 17
    Wechsler D. Wechsler’s Intelligence Scale for Children, 3rd edn. London: Harcourt Brace, 1992.
  • 18
    Hardy KK, Willard VW, Bonner MJ. Computerized cognitive training in survivors of childhood cancer: a pilot study. J Pediatr Oncol Nurs2011; 28: 2733.
  • 19
    O’Neil S, Ji LY, Buranahirun C, et al.Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. Pediatr Blood Cancer2011; 57: 66973.
  • 20
    Strauss E, Sherman EMS, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms and Commentary, 3rd edn. New York, NY: Oxford University Press, 2006.
  • 21
    Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analysis. (accessed 1 November 2011).
  • 22
    Borenstein M, Rothstein H. Comprehensive Meta-Analysis, A Computer Program for Research Synthesis, 2nd edn. Englewood, NJ: Biostat, 1999.
  • 23
    Jalali R, Goswami S, Sarin R, More N, Siddha M, Kamble R. Neuropsychological status in children and young adults with benign and low-grade brain tumors treated prospectively with focal stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys2006; 66: S149.
  • 24
    Lacaze E, Kieffer V, Streri A, et al.Neuropsychological outcome in children with optic pathway tumours when first-line treatment is chemotherapy. Br J Cancer2003; 89: 203844.
  • 25
    Merchant TE, Sherwood SH, Mulhern RK, et al.CNS germinoma: disease control and long-term functional outcome for 12 children treated with craniospinal irradiation. Int J Radiat Oncol Biol Phys2000; 46: 11716.
  • 26
    Ris MD, Beebe DW, Armstrong FD, et al.Cognitive and adaptive outcome in extracerebellar low-grade brain tumors in children: a report from the Children’s Oncology Group. J Clin Oncol2008; 26: 476570.
  • 27
    Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol2005; 5: 13.
  • 28
    Cohen J. The statistical power of abnormal-social psychological research: a review. J Abnorm Soc Psychol1962; 65: 14553.
  • 29
    Aukema EJ, Caan MW, Oudhuis N, et al.White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors. Int J Radiat Oncol Biol Phys2009; 74: 83743.
  • 30
    Gliner JA, Morgan GA, Harmon RJ. Meta-analysis: formulation and interpretation. J Am Acad Child Adolesc Psychiatry2003; 42: 13769.
  • 31
    Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index?Psychol Methods2006; 11: 193206.
  • 32
    Conklin HM, Khan RB, Reddick WE, et al.Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial. J Pediatr Psychol2007; 32: 112739.
  • 33
    Mulhern RK, Palmer SL, Reddick WE, et al.Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. J Clin Oncol2001; 19: 4729.
  • 34
    Spiegler BJ, Bouffet E, Greenberg ML, Rutka JT, Mabbott DJ. Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol2004; 22: 70613.
  • 35
    Rosenthal R. Writing meta-analytic reviews. Psychol Bull1995; 118: 18392.
  • 36
    Saury JMG, Emanuelson I. Cognitive consequences of the treatment of medulloblastoma among children. Pediatr Neurol2011; 44: 2130.
  • 37
    Sands SA, Oberg JA, Gardner SL, Whiteley JA, Glade-Bender JL, Finlay JL. Neuropsychological functioning of children treated with intensive chemotherapy followed by myeloablative consolidation chemotherapy and autologous hematopoietic cell rescue for newly diagnosed CNS tumors: an analysis of the head start II survivors. Pediatr Blood Cancer2010; 54: 42936.
  • 38
    Bonner MJ, Hardy KK, Willard VW, Gururangan S. Additional evidence of a nonverbal learning disability in survivors of pediatric brain tumors. Childrens Health Care2009; 38: 4963.
  • 39
    Callu D, Viguier D, Laroussinie F, et al.Cognitive and academic outcome after benign or malignant cerebellar tumor in children. Cogn Behav Neurol2009; 22: 2708.
  • 40
    Briere ME, Scott JG, McNall-Knapp RY, Adams RL. Cognitive outcome in pediatric brain tumor survivors: delayed attention deficit at long-term follow-up. Pediatr Blood Cancer2008; 50: 33740.
  • 41
    Sanders RP, Kocak M, Burger PC, Merchant TE, Gajjar A, Broniscer A. High-grade astrocytoma in very young children. Pediatr Blood Cancer2007; 49: 88893.
  • 42
    Khong PL, Leung LH, Fung AS, et al.White matter anisotropy in post-treatment childhood cancer survivors: preliminary evidence of association with neurocognitive function. J Clin Oncol2006; 24: 88490.
  • 43
    Beebe DW, Ris MD, Armstrong FD, et al.Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in national collaborative research studies (CCG 9891/POG 9130). J Clin Oncol2005; 23: 5198204.
  • 44
    Grill J, Viguier D, Kieffer V, et al.Critical risk factors for intellectual impairment in children with posterior fossa tumors: the role of cerebellar damage. J Neurosurg2004; 101: 1528.
  • 45
    Packer RJ. Radiation-induced neurocognitive decline: the risks and benefits of reducing the amount of whole-brain irradiation. Curr Neurol Neurosci Rep2002; 2: 1313.
  • 46
    Carey ME, Barakat LP, Foley B, Gyato K, Phillips PC. Neuropsychological functioning and social functioning of survivors of pediatric brain tumors: evidence of nonverbal learning disability. Child Neuropsychol2001; 7: 26572.
  • 47
    Kieffer-Renaux V, Bulteau C, Grill J, Kalifa C, Viguier D, Jambaque I. Patterns of neuropsychological deficits in children with medulloblastoma according to craniospatial irradiation doses. Dev Med Child Neurol2000; 42: 7415.
  • 48
    Mulhern RK, Reddick WE, Palmer SL, et al.Neurocognitive deficits in medulloblastoma survivors and white matter loss. Ann Neurol1999; 46: 83441.
  • 49
    Hazin I, Dellatolas G, Garcia D, Pedrosa F, Pedrosa A. Intellectual Impairment after treatment for medulloblastoma and astrocytoma in childhood: the Brazilian experience. J Pediatr Hematol Oncol2011; 33: 50615.
  • 50
    Butler RW, Copeland DR, Fairclough DL, et al.A multicenter, randomized clinical trial of a cognitive remediation program for childhood survivors of a pediatric malignancy. J Consult Clin Psychol2008; 76: 36778.
  • 51
    Mabbott DJ, Penkman L, Witol A, Strother D, Bouffet E. Core neurocognitive functions in children treated for posterior fossa tumors. Neuropsychology2008; 22: 15968.
  • 52
    Stargatt R, Rosenfeld JV, Maixner W, Ashley D. Multiple factors contribute to neuropsychological outcome in children with posterior fossa tumors. Dev Neuropsychol2007; 32: 72948.
  • 53
    Reeves CB, Palmer SL, Reddick WE, et al.Attention and memory functioning among pediatric patients with medulloblastoma. J Pediatr Psychol2006; 31: 27280.
  • 54
    Mulhern RK, White HA, Glass JO, et al.Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood. J Int Neuropsychol Soc2004; 10: 1809.
  • 55
    Deary I, Strand S, Smith P, Fernandes C. Intelligence and educational achievement. Intelligence2007; 35: 1321.
  • 56
    Watkins MW, Lei P, Canivez GL. Psychometric intelligence and achievement: a cross-lagged panel analysis. Intelligence2007; 35: 5968.
  • 57
    Reddick WE, White HA, Glass JO, et al.Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer2003; 97: 25129.
  • 58
    de Boer AG, Verbeek JH, van Dijk FJ. Adult survivors of childhood cancer and unemployment: a metaanalysis. Cancer2006; 107: 111.
  • 59
    Anderson V, Northam E, Hendy J, Wrennall J. Developmental Neuropsychology; A Clinical Approach. Hove, East Sussex: Psychology Press, 2001.
  • 60
    Johnson S. Cognitive and behavioural outcomes following very preterm birth. Semin Fetal Neonatal Med2007; 12: 36373.
  • 61
    Cantelmi D, Schweizer TA, Cusimano MD. Role of the cerebellum in the neurocognitive sequelae of treatment of tumours of the posterior fossa: an update. Lancet Oncol2008; 9: 56976.
  • 62
    Salman MS. The cerebellum: it’s about time! But timing is not everything–new insights into the role of the cerebellum in timing motor and cognitive tasks. J Child Neurol2002; 17: 19.
  • 63
    Copeland DR, deMoor C, Moore BD III, Ater JL. Neurocognitive development of children after a cerebellar tumor in infancy: a longitudinal study. J Clin Oncol1999; 17: 347686.
  • 64
    Monje M, Dietrich J. Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis. Behav Brain Res2012; 227: 3769.
  • 65
    Dockstader C, Gaetz W, Rockel C, Mabbott DJ. White matter maturation in visual and motor areas predicts the latency of visual activation in children. Hum Brain Mapp2012; 33: 17991.
  • 66
    Dennis M, Hetherington CR, Spiegler BJ. Memory and attention after childhood brain tumors. Med Pediatr Oncol1998; 30 (Suppl. 1) 2533.
  • 67
    Netson KL, Conklin HM, Ashford JM, Kahalley LS, Wu S, Xiong X. Parent and teacher ratings of attention during a year-long methylphenidate trial in children treated for cancer. J Pediatr Psychol2011; 36: 43850.
  • 68
    Kahalley LS, Conklin HM, Tyc VL, et al.ADHD and secondary ADHD criteria fail to identify many at-risk survivors of pediatric ALL and brain tumor. Pediatr Blood Cancer2011; 57: 1108.
  • 69
    Kiehna EN, Mulhern RK, Li C, Xiong X, Merchant TE. Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy. J Clin Oncol2006; 24: 528390.
  • 70
    Rubia K, Smith AB, Brammer MJ, Taylor E. Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage2003; 20: 3518.
  • 71
    Han R, Yang YM, Dietrich J, Luebke A, Mayer-Proschel M, Noble M. Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system. J Biol2008; 7: 12.
  • 72
    Mulhern RK, Merchant TE, Gajjar A, Reddick WE, Kun LE. Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol2004; 5: 399408.