An update on the prevalence of cerebral palsy: a systematic review and meta-analysis

Authors

  • Maryam Oskoui,

    Corresponding author
    • Departments of Pediatrics and Neurology, McGill University, Montreal, Quebec, Canada
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  • Franzina Coutinho,

    1. School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
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  • Jonathan Dykeman,

    1. Department of Clinical Neurosciences and Hotchkiss Brain Institute, Department of Community Health Sciences and Institute of Public Health, University of Calgary, Calgary, Alberta, Canada
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  • Nathalie Jetté,

    1. Department of Clinical Neurosciences and Hotchkiss Brain Institute, Department of Community Health Sciences and Institute of Public Health, University of Calgary, Calgary, Alberta, Canada
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  • Tamara Pringsheim

    1. Departments of Clinical Neurosciences and Pediatrics, University of Calgary, Calgary, Alberta, Canada
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Errata

This article is corrected by:

  1. Errata: Erratum Volume 58, Issue 3, 316, Article first published online: 18 February 2016

Correspondence to Dr Maryam Oskoui, Departments of Pediatrics and Neurology, McGill University, Montreal Children's Hospital, 2300 Tupper Street, A-512, Montreal, Quebec, Canada H3H 1P3. E-mail: maryam.oskoui@mcgill.ca

Abstract

Aims

The aim of this study was to provide a comprehensive update on (1) the overall prevalence of cerebral palsy (CP); (2) the prevalence of CP in relation to birthweight; and (3) the prevalence of CP in relation to gestational age.

Method

A systematic review and meta-analysis was conducted and reported, based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Population-based studies on the prevalence of CP in children born in 1985 or after were selected. Statistical analysis was carried out using computer package R, version 2.14.

Results

A total of 49 studies were selected for this review. The pooled overall prevalence of CP was 2.11 per 1000 live births (95% confidence interval [CI] 1.98–2.25). The prevalence of CP stratified by gestational age group showed the highest pooled prevalence to be in children weighing 1000 to 1499g at birth (59.18 per 1000 live births; 95% CI 53.06–66.01), although there was no significant difference on pairwise meta-regression with children weighing less than 1000g. The prevalence of CP expressed by gestational age was highest in children born before 28 weeks' gestation (111.80 per 1000 live births; 95% CI 69.53–179.78; p<0.0327).

Interpretation

The overall prevalence of CP has remained constant in recent years despite increased survival of at-risk preterm infants.

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