These authors contributed equally to this article.
The potential for stem cell therapies to have an impact on cerebral palsy: opportunities and limitations
Version of Record online: 16 MAY 2013
© 2013 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 55, Issue 8, pages 689–697, August 2013
How to Cite
Ruff, C. A., Faulkner, S. D. and Fehlings, M. G. (2013), The potential for stem cell therapies to have an impact on cerebral palsy: opportunities and limitations. Developmental Medicine & Child Neurology, 55: 689–697. doi: 10.1111/dmcn.12166
- Issue online: 9 JUL 2013
- Version of Record online: 16 MAY 2013
- Manuscript Accepted: 2 MAR 2013
Cerebral palsy (CP) is a chronic childhood disorder described by a group of motor and cognitive impairments and results in a substantial socio-economic burden to the individual, family, and healthcare system. With no effective biological interventions, therapies for CP are currently restricted to supportive and management strategies. Cellular transplantation has been suggested as a putative intervention for neural pathology, as mesenchymal and neural stem cells, as well as olfactory ensheathing glia and Schwann cells, have shown some regenerative and functional efficacy in experimental central nervous system disorders. This review describes the most common cell types investigated and delineates their purported mechanisms in vivo. Furthermore, it provides a cogent summary of both current early-phase clinical trials using neural precursor cells (NPCs) and the state of stem cell therapies for neurodegenerative conditions. Although NPCs are perhaps the most promising candidates for cell replacement therapy in the context of CP, much still remains to be understood regarding safety, efficacy, timing, dose, and route of transplantation, as well as the capacity for combinatorial strategies.