Neurophysiological abnormalities in the sensorimotor cortices during the motor planning and movement execution stages of children with cerebral palsy
Article first published online: 14 JUN 2014
© 2014 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 56, Issue 11, pages 1072–1077, November 2014
How to Cite
Kurz, M. J., Becker, K. M., Heinrichs-Graham, E. and Wilson, T. W. (2014), Neurophysiological abnormalities in the sensorimotor cortices during the motor planning and movement execution stages of children with cerebral palsy. Developmental Medicine & Child Neurology, 56: 1072–1077. doi: 10.1111/dmcn.12513
- Issue published online: 9 OCT 2014
- Article first published online: 14 JUN 2014
- Manuscript Accepted: 11 APR 2014
- Hattie B Monroe Foundation
- National Institutes of Health. Grant Number: 1R21HD077532-01
This investigation used magnetoencephalography (MEG) to examine the neural oscillatory responses of the sensorimotor cortices during the motor planning and movement execution stages of children with typical development and children with cerebral palsy (CP).
The study involved 13 children with CP (nine males, four females; mean [SD] age 14y 3mo [9mo], range 10–18y; height 1.61m [0.08m]; weight 52.65kg [13kg]), and 13 age- and sex-matched typically developing children (height 1.64m [0.06m]; weight 56.88kg [10kg]). The experiment required the children to extend their knee joint as whole-head MEG recordings were acquired. Beamformer imaging methods were employed to quantify the source activity of the beta-frequency (14–28Hz) event-related desynchronization (ERD) that occurs during the motor planning period, and the gamma-frequency (~50Hz) event-related synchronization (ERS) that occurs at the motor execution stage.
The children with CP had a stronger mean beta ERD during the motor planning phase and reduced mean gamma ERS at the onset of movement.
The uncharacteristic beta ERD in the children with CP suggests that they may have greater difficulty planning knee joint movements. We suggest that these aberrant beta ERD oscillations may have a cascading effect on the gamma ERS, which ultimately affects the execution of the motor command.