Short Report: Epidemiology
Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families
Article first published online: 13 JUL 2013
© 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK
Volume 31, Issue 1, pages 31–35, January 2014
How to Cite
Diabet. Med. 31, 31–35 (2014)
- Issue published online: 12 DEC 2013
- Article first published online: 13 JUL 2013
- Accepted manuscript online: 24 JUN 2013 09:41AM EST
- Manuscript Accepted: 18 JUN 2013
- National Institutes of Health (NIH). Grant Numbers: R01 DK082610, R01 DK079169, P01 HL045522, R37 MH059490
- AT&T Foundation
- National Center for Research Resources. Grant Number: S10 RR029392
- Research Facilities Improvement Program. Grant Numbers: C06 RR013556, C06 RR017515
We aimed to determine the genetic and environmental correlation between various anthropometric indexes and incident Type 2 diabetes with a focus on waist circumference.
We used the data on extended Mexican-American families (808 subjects, 7617.92 person-years follow-up) from the San Antonio Family Heart Study and estimated the genetic and environmental correlations of 16 anthropometric indexes with the genetic liability of incident Type 2 diabetes. We performed bivariate trait analyses using the solar software package.
All 16 anthropometric indexes were significantly heritable (range of heritabilities 0.24–0.99). Thirteen indexes were found to have significant environmental correlation with the liability of incident Type 2 diabetes. In contrast, only anthropometric indexes consisting of waist circumference (waist circumference, waist–hip ratio and waist–height ratio) were significantly genetically correlated (genetic correlation coefficients: 0.45, 0.55 and 0.44, respectively) with the liability of incident Type 2 diabetes. We did not observe such a correlation for BMI.
Waist circumference as a predictor of future Type 2 diabetes is supported by the finding that they share common genetic influences.