Two-hour post-load plasma glucose levels are associated with carotid intima-media thickness in subjects with normal glucose tolerance
Article first published online: 19 AUG 2013
© 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK
Volume 31, Issue 1, pages 76–83, January 2014
How to Cite
Diabet. Med. 31, 76–83 (2014)
- Issue published online: 12 DEC 2013
- Article first published online: 19 AUG 2013
- Accepted manuscript online: 22 JUL 2013 01:18AM EST
- Manuscript Accepted: 16 JUL 2013
- Manuscript Revised: 5 JUL 2013
- Manuscript Received: 1 APR 2013
Elevated post-load plasma glucose levels may increase the risk of cardiovascular disease, even when they are within the normoglycaemic range. We examined the association of carotid artery intima-media thickness, a marker of early atherosclerosis, with glycaemic variables, including post-load plasma glucose levels, in Japanese subjects with normal glucose tolerance.
The study participants were 663 Japanese subjects with normal glucose tolerance (565 men, mean age 47 ± 9 years) who underwent both a 75-g oral glucose tolerance test and carotid artery intima-media thickness measurement by B-mode ultrasonography during a health examination. Associations between maximal common carotid artery intima-media thickness and fasting plasma glucose, 1-h and 2-h plasma glucose during an oral glucose tolerance test, and HbA1c were examined.
The carotid artery intima-media thickness gradually increased across the tertiles of 1-h plasma glucose, 2-h plasma glucose and HbA1c. In multiple linear regression analysis, 2-h plasma glucose (β = 0.09, P = 0.012), as well as age, male gender, hypertension, dyslipidaemia, and current smoking were independent determinants of carotid artery intima-media thickness. In contrast, other glycaemic variables were not independent determinants of carotid artery intima-media thickness. The carotid artery intima-media thickness in hypertensive subjects with the highest tertile of 2-h plasma glucose [0.70 (95% CI 0.64–0.76) mm] was significantly greater than in normotensive subjects, with the lowest tertile of 2-h plasma glucose [0.60 (95% CI 0.58–0.63) mm, P = 0.037], even after adjusting for the multiple potential confounders.
The 2-h plasma glucose during an oral glucose tolerance test was positively and independently associated with carotid artery intima-media thickness in Japanese subjects with normal glucose tolerance. In particular, the combination of elevated 2-h plasma glucose and hypertension may contribute to an increased carotid artery intima-media thickness.