Diabetic Medicine

Cover image for Vol. 30 Issue 11

November 2013

Volume 30, Issue 11

Pages 1267–1389

  1. Editor's Selection: This Month's Highlighted Articles

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letter
  2. Review Article

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letter
  3. Systematic Review or Meta-analysis

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letter
  4. Research Articles

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letter
    1. Treatment

      You have full text access to this OnlineOpen article
      Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal–bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN® Basal–Bolus Type 1): 2-year results of a randomized clinical trial (pages 1293–1297)

      B. W. Bode, J. B. Buse, M. Fisher, S. K. Garg, M. Marre, L. Merker, E. Renard, D. L. Russell-Jones, C. T. Hansen, A. Rana, S. R. Heller and on behalf of theBEGIN® Basal–Bolus Type 1 Trial Investigators

      Article first published online: 17 JUN 2013 | DOI: 10.1111/dme.12243

      What's new?

      • Insulin degludec is the first basal insulin analogue with an ultra-long duration of action for the treatment of Type 1 and Type 2 diabetes mellitus.
      • The pharmacokinetic and pharmacodynamic profile of insulin degludec results in similar efficacy but reduces the risk of nocturnal hypoglycaemia compared with currently marketed basal insulins.
      • This multi-centre, multinational, 2-year study reaffirms the long-term safety and efficacy of insulin degludec in patients with Type 1 diabetes in a basal–bolus regimen with insulin aspart.
    2. You have full text access to this OnlineOpen article
      Comparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial (pages 1298–1304)

      H. W. Rodbard, B. Cariou, B. Zinman, Y. Handelsman, A. Philis-Tsimikas, T. V. Skjøth, A. Rana, C. Mathieu and on behalf of The BEGIN Once Long Trial Investigators

      Article first published online: 30 SEP 2013 | DOI: 10.1111/dme.12303

      What's new?

      • Insulin degludec, a basal insulin analogue, uses a novel protraction mechanism, resulting in a flat, stable profile and a duration of action greater than 42 h.
      • Consistent with its pharmacokinetic and pharmacodynamic profile, insulin degludec in combination with oral anti-diabetic drugs provided long-term glycaemic control similar to insulin glargine with a lower risk for nocturnal hypoglycaemia in insulin-naive patients with Type 2 diabetes, in a 1-year, randomized study.
      • This extension study reports 2-year data, confirming that insulin degludec in combination with oral anti-diabetic drugs maintains stable glycaemic control with a sustained benefit in reducing hypoglycaemic risk in Type 2 diabetes.
    3. The association between adherence to oral anti-diabetic drugs and hypoglycaemia in persons with Type 2 diabetes (pages 1305–1313)

      B. J. Quilliam, A. B. Ozbay, B. E. Sill and S. J. Kogut

      Article first published online: 23 MAY 2013 | DOI: 10.1111/dme.12217

      What's new?

      • Hypoglycaemia is a major hindrance to treatment with oral anti-diabetic drugs in persons with Type 2 diabetes; adherence to medication may contribute to the occurrence of hypoglycaemia.
      • This study evaluates the relation between adherence to newly initiated oral anti-diabetic drugs and rate of incident hypoglycaemia resulting in a medical encounter.
    4. You have full text access to this OnlineOpen article
      A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes (pages 1314–1323)

      S. C. McGeoch, A. M. Johnstone, G. E. Lobley, J. Adamson, K. Hickson, G. Holtrop, C. Fyfe, L. F. Clark, D. W. M. Pearson, P. Abraham, I. L. Megson and S. M. MacRury

      Article first published online: 22 JUN 2013 | DOI: 10.1111/dme.12228

      What's new?

      • No differences were observed in measurements of glycaemic control following either chronic intervention with the oat-enriched diet or acutely following an oat-enriched meal.
      • A small beneficial effect of oats on plasma lipid profiles was observed that may have implications for reducing cardiovascular risk profiles.
      • Consumption of a relatively healthy test meal produced smaller inflammatory responses than reported using either artificially high fat or carbohydrate loads.
      • Results reinforce the importance of adhering to healthy eating advice in Type 2 diabetes in terms of reducing systemic levels of inflammation and oxidative stress and therefore cardiovascular risk.
    5. Pathophysiology

      Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study (pages 1324–1332)

      N. S. The, J. L. Crandell, J. M. Lawrence, I. B. King, D. Dabelea, S. M. Marcovina, R. B. D'Agostino Jr, J. M. Norris, C. Pihoker and E. J. Mayer-Davis

      Article first published online: 29 AUG 2013 | DOI: 10.1111/dme.12297

      What's new?

      • The identification of modifiable factors that improve insulin resistance may be critical for improving long-term health outcomes for individuals with Type 1 diabetes.
      • Previous studies examining the relation of vitamin D with insulin resistance have reported inconsistent findings.
      • Most research in this area has been conducted using cross-sectional designs and in individuals without diabetes, thus precluding the generalizability of these findings to at-risk populations.
      • Determining the relation of vitamin D with insulin in a diverse, contemporary cohort of youth with Type 1 diabetes may have implications for short- and long-term health.
    6. Epidemiology

      Concordance of retinopathy and nephropathy over time in Type 1 diabetes: an analysis of data from the Diabetes Control and Complications Trial (pages 1333–1341)

      C. K. Kramer and R. Retnakaran

      Article first published online: 28 AUG 2013 | DOI: 10.1111/dme.12296

      What's new?

      • Approximately one quarter of participants (23.6%) had discordant progression of diabetic retinal and renal disease during the Diabetes Control and Complications Trial.
      • Importantly, progression of diabetic retinopathy significantly increased the risk for development of diabetic nephropathy independently of established risk factors for microvascular complications.
      • Similarly, the development of diabetic nephropathy independently increased the risk for diabetic retinopathy progression.
      • These data potentially support the notion of a shared aetiologic basis and suggest that, in practice, the detection of either diabetic retinopathy progression or diabetic nephropathy development may indicate a need for closer surveillance for the other complication.
    7. You have full text access to this OnlineOpen article
      Urinary C-peptide creatinine ratio detects absolute insulin deficiency in Type 2 diabetes (pages 1342–1348)

      S. V. Hope, A. G. Jones, E. Goodchild, M. Shepherd, R. E. J. Besser, B. Shields, T. McDonald, B. A. Knight and A. Hattersley

      Article first published online: 12 JUN 2013 | DOI: 10.1111/dme.12222

    8. Epidemiology of blindness attributable to diabetes in Scotland: change over 20 years in a defined population (pages 1349–1354)

      H. N. Hall, D. J. Chinn, A. Sinclair and C. J. Styles

      Article first published online: 7 JUN 2013 | DOI: 10.1111/dme.12223

      What's new?

      • This study establishes the incidence and prevalence of registered blindness attributable to diabetes in a defined population in Scotland, in both the total population and the population of people with diabetes, and examines the change in epidemiology over 20 years.
      • We report a reduction in the incidence of blindness attributable to diabetes in the population with diabetes during the period 2000–2009.
      • The population with diabetes used in the calculations is taken from a central diabetes register rather than from estimations using epidemiological modelling.
      • These data provide a baseline against which the introduction of screening for diabetic eye disease and its impact on vision loss can be assessed.
    9. Association of living alone with the presence of undiagnosed diabetes in Japanese men: the role of modifiable risk factors for diabetes: Toranomon Hospital Health Management Center Study 13 (TOPICS 13) (pages 1355–1359)

      Y. Heianza, Y. Arase, S. Kodama, S. D. Hsieh, H. Tsuji, K. Saito, H. Shimano, S. Hara and H. Sone

      Article first published online: 9 JUL 2013 | DOI: 10.1111/dme.12255

      What's new?

      • This study, involving a cohort of apparently healthy Japanese men, showed that living alone was associated with prevalent undiagnosed diabetes and that this association could be influenced by addressing modifiable lifestyle risk factors for Type 2 diabetes.
      • Men who live alone and who are also overweight, have a current smoking habit, or are physically inactive have a high probability of having undetected diabetes.
    10. Complications

      Factors associated with diabetic ketoacidosis at onset of Type 1 diabetes in children and adolescents (pages 1360–1366)

      L. de Vries, L. Oren, L. Lazar, Y. Lebenthal, S. Shalitin and M. Phillip

      Article first published online: 9 JUL 2013 | DOI: 10.1111/dme.12252

      What's new?

      • Risk factors for diabetic ketoacidosis at diagnosis did not change over two decades.
      • Children aged < 2 years and children of Ethiopian Jewish origin are at high risk for diabetic ketoacidosis at diagnosis.
      • Factors associated with lower risk were Type 1 diabetes in a first- and/or second-degree family member, screening tests for hyperglycaemia at the community clinic prior to admission, higher weight standard deviation score and older age at diagnosis.
      • Recognizing the risk factors for diabetic ketoacidosis at presentation would be the basis for a targeted prevention programme aimed at increasing awareness and knowledge of the clinical symptoms.
    11. Association between serum ferritin and microalbuminuria in Type 2 diabetes in Taiwan (pages 1367–1373)

      Y. H. Hsu, M. C. Huang, H. Y. Chang, S. J. Shin, M. L. Wahlqvist, Y. L. Chang, K. C. Hsu and C. C. Hsu

      Article first published online: 9 JUL 2013 | DOI: 10.1111/dme.12257

      What's new?

      • A significant relationship has been found between serum ferritin and microalbuminuria, indicating that iron overload may be a risk factor of diabetic nephropathy.
      • Although ferritin may be an inflammatory marker in addition to a measure of iron concentration, the newly discovered relationship between hyperferritinemia and microalbuminuria seems to be independent of other inflammatory biomarkers such as high-sensitivity C-reactive protein and white blood cell count.
    12. Care Delivery

      Real-time continuous glucose monitoring during labour and delivery in women with Type 1 diabetes — observations from a randomized controlled trial (pages 1374–1381)

      S. Cordua, A. L. Secher, L. Ringholm, P. Damm and E. R. Mathiesen

      Article first published online: 26 JUL 2013 | DOI: 10.1111/dme.12246

      What's new?

      • In women with Type 1 diabetes using real-time continuous glucose monitoring supplementary to hourly self-monitored plasma glucose measurements during labour and delivery, the prevalence of neonatal hypoglycaemia was comparable with that of infants of women solely using self-monitored plasma glucose.
      • Despite median plasma glucose values within target range, mothers of infants with neonatal hypoglycaemia spent more time with glucose levels > 7.0 mmol/l during the last 8 h up to delivery compared with mothers of infants without neonatal hypoglycaemia.
      • Maternal hypoglycaemia during the last 8 h up to delivery was relatively rare with this protocol on subcutaneous insulin administration.
    13. Importance of factors determining the low health-related quality of life in people presenting with a diabetic foot ulcer: the Eurodiale study (pages 1382–1387)

      V. Siersma, H. Thorsen, P. E. Holstein, M. Kars, J. Apelqvist, E. B. Jude, A. Piaggesi, K. Bakker, M. Edmonds, A. Jirkovska, D. Mauricio, G. Ragnarson Tennvall, H. Reike, M. Spraul, L. Uccioli, V. Urbancic, K. van Acker, J. van Baal and N. C. Schaper

      Article first published online: 15 JUL 2013 | DOI: 10.1111/dme.12254

      What's new?

      • The inability to stand or walk without help is the most important determinant of poor health-related quality of life. Other factors with high importance are ulcer size, elevated C-reactive protein concentration and limb-threatening ischaemia.
      • To improve health-related quality of life, treatment should not only be focused on ulcer healing but a multifactorial approach by a specialized multidisciplinary team is also important.
  5. Letter

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letter
    1. Glycated albumin and continuous glucose monitoring to replace glycated haemoglobin in patients with diabetes treated with haemodialysis (pages 1388–1389)

      L. Meyer, F. Chantrel, O. Imhoff, A. Sissoko, L. Serb, F. Dorey, D. Fleury, A. Smagala, L. Kepenekian, T. Krummel, J.-P. Le Floch and L. Kessler

      Article first published online: 17 OCT 2013 | DOI: 10.1111/dme.12294

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