Diabetic Medicine

© 2013 Diabetes UK

Cover image for Vol. 30 Issue 6

June 2013

Volume 30, Issue 6

Pages 637–764, e201–e232

  1. Editor's Selection

    1. Top of page
    2. Editor's Selection
    3. Review Articles
    4. Research Articles
    5. Letters
    6. Fast Tracked Online Articles
    7. Research Articles
    1. You have free access to this content
      Harry Keen and screening young adults for cardiometabolic disease (page 637)

      G. A. Hitman

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12221

    2. You have free access to this content
      Professor Harry Keen, champion of people with diabetes worldwide (pages 638–639)

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12221_1

  2. Review Articles

    1. Top of page
    2. Editor's Selection
    3. Review Articles
    4. Research Articles
    5. Letters
    6. Fast Tracked Online Articles
    7. Research Articles
    1. You have free access to this content
      Diabetic retinopathy: pathogenesis, clinical grading, management and future developments (pages 640–650)

      L. Z. Heng, O. Comyn, T. Peto, C. Tadros, E. Ng, S. Sivaprasad and P. G. Hykin

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12089

    2. You have free access to this content
      Influence of glucocorticoids and growth hormone on insulin sensitivity in humans (pages 651–663)

      K. C. J. Yuen, L. E. Chong and M. C. Riddle

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12184

    3. You have free access to this content
      Assessment of insulin action on carbohydrate metabolism: physiological and non-physiological methods (pages 664–670)

      S. Dube, I. Errazuriz, C. Cobelli, R. Basu and A. Basu

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12189

  3. Research Articles

    1. Top of page
    2. Editor's Selection
    3. Review Articles
    4. Research Articles
    5. Letters
    6. Fast Tracked Online Articles
    7. Research Articles

    1. Epidemiology

      Prevalence of diabetes and impaired glucose metabolism in younger ‘at risk’ UK adults: insights from the STAND programme of research (pages 671–675)

      E. G. Wilmot, C. L. Edwardson, S. J. H. Biddle, T. Gorely, J. Henson, K. Khunti, M. A. Nimmo, T. Yates and M. J. Davies

      Article first published online: 12 APR 2013 | DOI: 10.1111/dme.12173

      What's new?

      • NICE guidance (2012) recommends screening younger high-risk individuals (aged 25–39 years) for diabetes.
      • There is a lack of data on the prevalence of screen-detected diabetes and impaired glucose metabolism in younger high-risk UK adults.
      • A cohort of younger ‘at risk’ UK adults underwent an oral glucose tolerance test and HbA1c: 4.7% were diagnosed with Type 2 diabetes; 18.1% had impaired glucose metabolism.
      • These findings lend support to the recent NICE recommendations but will require confirmation in larger studies.
    2. Association between duration and quality of sleep and the risk of pre-diabetes: evidence from NHANES (pages 676–680)

      J. Engeda, B. Mezuk, S. Ratliff and Y. Ning

      Article first published online: 22 MAR 2013 | DOI: 10.1111/dme.12165

      What's new?

      • Use of fasting plasma glucose data and self-report to assess clinically identified and undiagnosed diabetes and pre-diabetes status.
      • Clinically identified pre-diabetes was associated with trouble maintaining sleep, waking up too early, and short sleep.

    3. Treatment

      You have full text access to this OnlineOpen article
      Primary-care observational database study of the efficacy of GLP-1 receptor agonists and insulin in the UK (pages 681–686)

      G. C. Hall, A. D. McMahon, M.-P. Dain, E. Wang and P. D. Home

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12137

    4. You have full text access to this OnlineOpen article
      Fasting plasma triglycerides predict the glycaemic response to treatment of Type 2 diabetes by gastric electrical stimulation. A novel lipotoxicity paradigm (pages 687–693)

      H. E. Lebovitz, B. Ludvik, I. Yaniv, W. Haddad, T. Schwartz and R. Aviv, Metacure Investigator Group

      Article first published online: 7 MAR 2013 | DOI: 10.1111/dme.12132

    5. Complications

      Higher levels of small dense low-density lipoprotein (LDL) are associated with cardiac autonomic neuropathy in patients with Type 2 diabetes (pages 694–701)

      E.-H. Jang, Y.-M. Park, J. Hur, M.-K. Kim, S.-H. Ko, K.-H. Baek, K.-H. Song, K.-W. Lee and H.-S. Kwon

      Article first published online: 7 APR 2013 | DOI: 10.1111/dme.12176

    6. Pathophysiology

      Effect of insulin on the soluble receptor for advanced glycation end products (RAGE) (pages 702–709)

      J. K. Y. Lam, Y. Wang, S. W. M. Shiu, Y. Wong, D. J. Betteridge and K. C. B. Tan

      Article first published online: 4 APR 2013 | DOI: 10.1111/dme.12166

    7. Genetics

      You have full text access to this OnlineOpen article
      HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype (pages 710–716)

      J. M. M. Howson, M. S. Roy, L. Zeitels, H. Stevens and J. A. Todd

      Article first published online: 21 MAR 2013 | DOI: 10.1111/dme.12148

      What's new?

      • This is the largest study in African Americans with Type 1 diabetes to date and the only study to account for ancestry.
      • This is the only study to date that fine maps the HLA region in African American samples using a dense map of 5147 single nucleotide polymorphisms and the class II genes.
      • We find HLA Type 1 diabetes associations that agree with known associations in Europeans, and novel associations of African ancestry specific alleles, e.g. HLA-DRB1*03:02, which confers protection from Type 1 diabetes.

    8. Care Delivery

      ‘The pump was a saviour for me.’Patients' experiences of insulin pump therapy (pages 717–723)

      A. Garmo, Å. Hörnsten and J. Leksell

      Article first published online: 15 MAR 2013 | DOI: 10.1111/dme.12155

    9. Type 1 diabetes structured education: what are the core self-management behaviours? (pages 724–730)

      L. Grant, J. Lawton, D. Hopkins, J. Elliott, S. Lucas, M. Clark, I. MacLellan, M. Davies, S. Heller and D. Cooke

      Article first published online: 21 MAR 2013 | DOI: 10.1111/dme.12164

    10. Determining in-patient diabetes treatment satisfaction in the UK—the DIPSat study (pages 731–738)

      C. L. Rutter, C. Jones, K. K. Dhatariya, J. James, L. Irvine, E. C. F. Wilson, H. Singh, E. Walden, R. Holland, I. Harvey, C. Bradley and M. J. Sampson

      Article first published online: 6 MAR 2013 | DOI: 10.1111/dme.12095

    11. Can computerized clinical decision support systems improve diabetes management? A systematic review and meta-analysis (pages 739–745)

      R. Jeffery, E. Iserman and R. B. Haynes, the CDSS Systematic Review Team

      Article first published online: 28 FEB 2013 | DOI: 10.1111/dme.12087

    12. Education and Psychological Aspects

      Evaluating a diabetes self-management support peer leader training programme for the English- and Punjabi-speaking South-Asian community in Vancouver (pages 746–752)

      T. S. Tang, P. S. Sohal and A. K. Garg

      Article first published online: 17 APR 2013 | DOI: 10.1111/dme.12179

  4. Letters

    1. Top of page
    2. Editor's Selection
    3. Review Articles
    4. Research Articles
    5. Letters
    6. Fast Tracked Online Articles
    7. Research Articles
    1. Is reduction in peak heart rate while exercising a sign of hypoglycaemia in athletes with diabetes mellitus? Response to Sacre et al. Diagnostic accuracy of heart-rate recovery after exercise in the assessment of diabetic cardiac autonomic neuropathy (pages 753–754)

      A. P. Morton

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12093

    2. Self-rated health and depression of patients with diabetes: how to handle with wide range of ageing and diabetic status? (pages 754–755)

      T. Kawada

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12143

    3. Response to Kawada: Self-rated health and depression of patients with diabetes: how to handle with wide range of ageing and diabetic status? (pages 755–756)

      G. Gariepy, G. Badawi, V. Pagé and N. Schmitz

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12142

    4. The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with Type 2 diabetes (pages 756–757)

      N. Matikainen and M.-R. Taskinen

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12094

    5. Systematic review of the development, implementation and availability of smart-phone applications for assessing Type 2 diabetes risk (pages 758–760)

      L. J. Gray, T. Leigh, M. J. Davies, N. Patel, M. Stone, M. Bonar, R. Badge and K. Khunti

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12115

    6. Evaluation of discharge coding for paediatric diabetic ketoacidosis (pages 760–761)

      R. L. Phillips, K. J. Noyes, L. E. Bath, C. M. Fischbacher and S. H. Wild

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12126

  5. Fast Tracked Online Articles

    1. Top of page
    2. Editor's Selection
    3. Review Articles
    4. Research Articles
    5. Letters
    6. Fast Tracked Online Articles
    7. Research Articles
    1. Abstracts of the Fast Tracked Online Articles (pages 762–764)

      Article first published online: 19 MAY 2013 | DOI: 10.1111/dme.12220

  6. Research Articles

    1. Top of page
    2. Editor's Selection
    3. Review Articles
    4. Research Articles
    5. Letters
    6. Fast Tracked Online Articles
    7. Research Articles

    1. Epidemiology

      Waist-to-height ratio is the best indicator for undiagnosed Type 2 diabetes (pages e201–e207)

      Z. Xu, X. Qi, A. K. Dahl and W. Xu

      Article first published online: 4 APR 2013 | DOI: 10.1111/dme.12168

    2. Complications

      The association between diabetes and an episode of depressive symptoms in the 2002 World Health Survey: an analysis of 231 797 individuals from 47 countries (pages e208–e214)

      P. M. C. Mommersteeg, R. Herr, F. Pouwer, R. I. G. Holt and A. Loerbroks

      Article first published online: 25 APR 2013 | DOI: 10.1111/dme.12193

      What's new?

      • The association between self-reported diabetes and an episode of depressive symptoms was examined, using data from the 2002 World Health Survey, including many low- and middle-income non-Western countries.
      • Diabetes was associated with an increased likelihood of an episode of depressive symptoms in Asia, South America and Europe, but not Africa.
      • These findings remained when adjusted for age, sex, years of education, BMI, smoking and physical activity level.
      • Given the global rise in diabetes in the coming decades, and the increased health risk of depression in diabetes, studies examining mechanisms and interventions are necessary.

    3. Care Delivery

      Prevalence of food insecurity in patients with diabetes in western Kenya (pages e215–e222)

      S. Cheng, J. Kamano, N. K. Kirui, E. Manuthu, V. Buckwalter, K. Ouma and S. D. Pastakia

      Article first published online: 12 APR 2013 | DOI: 10.1111/dme.12174

      What's new?

      • The focus on addressing the rising burden of diabetes has largely been on traditional risk factors such as caloric over-nutrition and a sedentary lifestyle.
      • In the rural resource-constrained setting analysed in the present study, many potential differences exist in both the presentation and causes of diabetes.
      • This study highlights the unique characteristics seen on initial presentation as approximately one-third of the patients in this study report food insecurity, with the overall population demonstrating lower BMIs and elevated initial HbA1c concentrations.
      • Contextualized prevention and management approaches need to be further investigated to better understand this population.
    4. Using the Medical Research Council framework to develop a complex intervention to improve delivery of care for young people with Type 1 diabetes (pages e223–e228)

      C. Eiser, B. Johnson, S. Brierley, K. Ayling, V. Young, K. Bottrell, V. Whitehead, J. Elliott, A. Scott and S. Heller

      Article first published online: 12 APR 2013 | DOI: 10.1111/dme.12185

      What's new?

      • We describe and discuss the development of a complex intervention for young people with Type 1 diabetes following the most recent MRC Guidelines.
      • We present brief findings from interviews with young people, staff and parents, systematic literature reviews and clinic audit, and show how these are used to determine key components of the intervention.
      • This innovative programme, specifically targeting young people (16–21 years), includes changes to standard care, an optional age-appropriate 5-day self-management course and a separate family communication intervention.
      • We discuss the strengths and weaknesses of the MRC Guidelines as a framework for developing complex interventions.

    5. Case Reports

      Charcot neuroarthropathy triggered and complicated by osteomyelitis. How limb salvage can be achieved (pages e229–e232)

      J. Aragón-Sánchez, J. L. Lázaro-Martínez, Y. Quintana-Marrero, F. J. Álvaro-Afonso and M. J. Hernández-Herrero

      Article first published online: 17 APR 2013 | DOI: 10.1111/dme.12191

      What's new?

      • The development of Charcot neuroarthropathy during conservative antibiotic treatment of osteomyelitis has not previously been addressed in the medical literature.
      • The possibility that bone inflammation, together with the absence of offloading, may act as the trigger for onset of acute Charcot neuroarthropathy should not be underestimated.
      • Interosseous oedema and bone debris attributable to Charcot neuroarthropathy become secondarily infected, causing a complex clinical picture that may lead to a major amputation.
      • We describe the previous events, which led to this challenging complication and give the keys to achieving limb salvage and a stable foot by means of a novel protocol.

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