Diabetic Medicine

Cover image for Vol. 30 Issue 8

August 2013

Volume 30, Issue 8

Pages 889–1012, e233–e242

  1. Invited Editorial

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
    1. Editor's Selection: This Month's Highlighted Articles

  2. Editorial

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
    1. Insulin allergy (pages 891–892)

      L. Heinzerling

      Version of Record online: 16 JUL 2013 | DOI: 10.1111/dme.12233

  3. Review Articles

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
  4. Research Articles

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
    1. Treatment

    2. Epidemiology

      The effects of patient characteristics and geographical region on hospitalization in patients with Type 2 diabetes (pages 918–925)

      M. J. Zaman, A. Patel, J. Chalmers, M. Woodward, P. Clarke, Q. Li and S. Zoungas

      Version of Record online: 12 APR 2013 | DOI: 10.1111/dme.12181

    3. Liver enzymes, race, gender and diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study (pages 926–933)

      A. L. C. Schneider, M. Lazo, C. E. Ndumele, J. S. Pankow, J. Coresh, J. M. Clark and E. Selvin

      Version of Record online: 12 APR 2013 | DOI: 10.1111/dme.12187

    4. Non-linear association between 25-hydroxyvitamin D and the incidence of Type 2 diabetes: a community-based nested case–control study (pages 934–938)

      M. Tohidi, M. Bozorgmanesh, R. Mohebi, D. Khalili, N. Saadat, N. Khorrami, F. Azizi and F. Hadaegh

      Version of Record online: 7 APR 2013 | DOI: 10.1111/dme.12180

      What's new?

      • Few prospective studies, having measured baseline serum 25-hydroxyvitamin D [25(OH)D], have studied the association between vitamin D status and the risk of newly diagnosed Type 2 diabetes.
      • Given the fact that 25(OH)D deficiency and Type 2 diabetes co-exist with a high prevalence among the Middle Eastern population, investigating if and how serum 25(OH)D concentrations contribute to the Type 2 diabetes incidence rate might be warranted. Using a community-based prospective study, we sought to examine the following: first, if serum 25(OH)D contributed to newly diagnosed Type 2 diabetes; and second, if a cutoff-point in the concentrations of 25(OH)D could be determined for identifying subjects at increased risk of Type 2 diabetes.
    5. Pathophysiology

      Objectively measured patterns of physical activity in primary school children in Coventry: the influence of ethnicity (pages 939–945)

      E. L. J. Eyre, M. J. Duncan, E. C. Smith and K. A. Matyka

      Version of Record online: 20 APR 2013 | DOI: 10.1111/dme.12186

      What's new?

      • South Asian children in Coventry are less physically active than their White European peers.
      • Patterns of activity suggest that these differences are mainly attributable to differences in after-school activity.
      • Young children spend, on average, only 30% of a 1-h physical education lesson engaged in health-enhancing physical activity.
    6. Exocrine pancreatic function in hepatocyte nuclear factor 1β-maturity-onset diabetes of the young (HNF1B-MODY) is only moderately reduced: compensatory hypersecretion from a hypoplastic pancreas (pages 946–955)

      E. Tjora, G. Wathle, F. Erchinger, T. Engjom, A. Molven, L. Aksnes, I. S. Haldorsen, G. Dimcevski, H. Ræder and P. R. Njølstad

      Version of Record online: 19 APR 2013 | DOI: 10.1111/dme.12190

      What's new?

      • The exocrine pancreatic function in HNF1B-MODY is moderately reduced.
      • Both ductal and acinar pancreatic function are affected in HNF1B-MODY.
      • Ductal function in HNF1B-MODY is dependent on the pancreatic gland size.
      • There is a compensatory hypersecretion in HNF1B-MODY as a response to secretin.
      • The small pancreas in HNF1B-MODY is probably attributable to hypoplasia, and not atrophy.
    7. Complications

    8. Amputations and foot ulcers in patients newly diagnosed with Type 2 diabetes mellitus and observed for 19 years. The role of age, gender and co-morbidity (pages 964–972)

      C. Bruun, V. Siersma, A. D. Guassora, P. Holstein and N. de Fine Olivarius

      Version of Record online: 26 APR 2013 | DOI: 10.1111/dme.12196

      What's new?

      • This paper presents the long-term natural course of foot complications in a population-based cohort of patients newly diagnosed with Type 2 diabetes.
      • Despite the last decades' improved treatment regimens, the incidence of lower-extremity amputations is still high.
      • Amputations are most often experienced by male patients diagnosed with diabetes at a relatively young age and by patients with diabetes-related co-morbidities.
      • These results underline the importance of prevention and prompt referral to specialized treatment in case of a developing foot ulcer in order to reduce the risk of amputation.
    9. Analysis of transfer lesions in patients who underwent surgery for diabetic foot ulcers located on the plantar aspect of the metatarsal heads (pages 973–976)

      R. J. Molines-Barroso, J. L. Lázaro-Martínez, J. Aragón-Sánchez, E. García-Morales, J. V. Beneit-Montesinos and F. J. Álvaro-Afonso

      Version of Record online: 20 APR 2013 | DOI: 10.1111/dme.12202

    10. Care Delivery

    11. Effect of online diabetes training for hospitalists on inpatient glycaemia (pages 994–998)

      R. Tamler, A. S. Dunn, D. E. Green, M. Skamagas, T. L. Breen, H. C. Looker and D. LeRoith

      Version of Record online: 21 MAR 2013 | DOI: 10.1111/dme.12151

    12. Health Economics

      Projection of the burden of Type 2 diabetes mellitus in Germany: a demographic modelling approach to estimate the direct medical excess costs from 2010 to 2040 (pages 999–1008)

      R. Waldeyer, R. Brinks, W. Rathmann, G. Giani and A. Icks

      Version of Record online: 18 MAY 2013 | DOI: 10.1111/dme.12177

      What's new?

      • The model predicts the future course of direct medical costs related to Type 2 diabetes from a societal perspective.
      • The model provides very country-specific information and is founded on large scenario analyses of different demographic, epidemiological and economic options.
      • The model is capable of reflecting the complex interplay of the underlying future forces of disease dynamics, but at the same time maintaining a clear and transparent structure.
      • A forecasting method of costs of chronic diseases is presented that can easily be adapted to other diseases and countries and could potentially anticipate the impacts of alternative policy scenarios.
  5. Letters

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
    1. The utility of retinal screening in gestational diabetes (pages 1009–1010)

      D. P. Macfarlane, E. P. O`Sullivan, S. Dorman, J. Allison, A. Ellingford, E. R. Pearson, G. J. Mires and G. P. Leese

      Version of Record online: 16 JUL 2013 | DOI: 10.1111/dme.12152

  6. Fast Tracked Online Articles

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
  7. Case Reports

    1. Top of page
    2. Invited Editorial
    3. Editorial
    4. Review Articles
    5. Research Articles
    6. Letters
    7. Fast Tracked Online Articles
    8. Case Reports
    1. Atypical phenotype associated with reported GCK exon 10 deletions: clinical judgement is needed alongside appropriate genetic investigations (pages e233–e238)

      G. Thanabalasingham, K. Kaur, F. Talbot, K. Colclough, A. Mathews, J. Taylor, S. Ellard and K. R. Owen

      Version of Record online: 16 JUL 2013 | DOI: 10.1111/dme.12210

      What's new?

      • Accurate diagnosis of the aetiology of diabetes is important to facilitate personalized medicine.
      • Consider monogenic diabetes in patients with atypical features of their diabetes ‘label’.
      • Definitive genetic tests are limited by both false positive and false negative results.
      • Clinicians should interpret the results of genetics tests within the specific clinical context.
    2. Late effects of childhood cancer treatment: severe hypertriglyceridaemia, central obesity, non alcoholic fatty liver disease and diabetes as complications of childhood total body irradiation (pages e239–e242)

      R. Rajendran, E. Abu, A. Fadl and C. D. Byrne

      Version of Record online: 16 JUL 2013 | DOI: 10.1111/dme.12234

      What's new?

      • A late complication of total body irradiation as a treatment for certain cancers (e.g. childhood leukaemias) is diabetes, occurring at a median of 9 years after treatment.
      • Emerging evidence now suggests that total body irradiation impairs preadipocyte differentiation and constrains future adipose tissue expansion and function.
      • In situations of calorie excess, because of impaired ability to expand subcutaneous adipose tissue depots in particular, triglyceride storage occurs in ectopic sites, including liver and visceral fat. Fat accumulation in these sites impairs insulin action, creating an exaggerated metabolic syndrome phenotype.
      • We report one such case presenting with life-threatening hypertriglyceridaemia.

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