Diabetic Medicine

Cover image for Diabetic Medicine

February 2014

Volume 31, Issue 2

Pages 121–249

  1. Editor's Selection: This Month's Highlighted Articles

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letters
    7. Corrections
    1. To tweet or not to tweet (page 121)

      G. A. Hitman and S. Finer

      Article first published online: 20 JAN 2014 | DOI: 10.1111/dme.12394

  2. Review Article

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letters
    7. Corrections
  3. Systematic Review or Meta-analysis

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letters
    7. Corrections
    1. Thyroid autoimmunity in Type 1 diabetes: systematic review and meta-analysis (pages 126–135)

      C. B. Shun, K. C. Donaghue, H. Phelan, S. M. Twigg and M. E. Craig

      Article first published online: 8 NOV 2013 | DOI: 10.1111/dme.12318

      What's new?

      • There are no systematic reviews/meta-analyses of thyroid dysfunction in Type 1 diabetes.
      • As thyroid autoimmunity is common in Type 1 diabetes, an evidence base to inform screening is needed.
      • The incidence of thyroid dysfunction ranged from 27 to 246 per 10 000 patient-years.
      • There was a strong association between thyroid autoimmunity and risk of thyroid dysfunction in people with Type 1 diabetes (risk ratio 25, 95% CI 9–71).
      • The optimal frequency of screening and type of test could not be determined because of the paucity of high-quality, longitudinal studies and lack of cost-effectiveness data.
    2. The effect of diabetic neuropathy on foot bones: a systematic review and meta-analysis (pages 136–147)

      A. L. Barwick, X. A. K. Janse de Jonge, J. W. Tessier, A. Ho and V. H. Chuter

      Article first published online: 20 JAN 2014 | DOI: 10.1111/dme.12347

  4. Research Articles

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letters
    7. Corrections
    1. Epidemiology

      You have full text access to this OnlineOpen article
      Changes in diet, cardiovascular risk factors and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort (pages 148–155)

      L. A. Savory, S. J. Griffin, K. M. Williams, A. T. Prevost, A.-L. Kinmonth, N. J. Wareham and R. K. Simmons

      Article first published online: 21 OCT 2013 | DOI: 10.1111/dme.12316

      What's new?

      • Dietary modification is an important first-line treatment option for clinically diagnosed patients.
      • Dietary changes in individuals with screen-detected diabetes may also be valuable. However, the lack of measurement of diet in previous trials makes it difficult to quantify the contribution that dietary change can make to cardiovascular risk reduction in this patient group.
      • Improvements in self-reported dietary behaviour and plasma vitamin C over 1 year in our screen-detected population were associated with small reductions in cardiovascular disease risk factors and modelled cardiovascular disease risk, independently of cardio-protective medication and physical activity.
      • Dietary change may have a role to play in the reduction of cardiovascular disease risk following diagnosis of diabetes.
    2. Patients with Type 1 diabetes consuming alcoholic spirits have an increased risk of microvascular complications (pages 156–164)

      V. Harjutsalo, M. Feodoroff, C. Forsblom, P.-H. Groop and on behalf of the FinnDiane Study Group

      Article first published online: 13 SEP 2013 | DOI: 10.1111/dme.12307

      What's new?

      • Only a few studies have previously addressed the association between alcohol consumption and diabetic microvascular complications with conflicting results.
      • Our study shows an association with alcohol consumption and diabetic nephropathy and severe retinopathy.
      • The lifelong abstainers and former users of alcohol have a higher risk of nephropathy and severe retinopathy compared with light consumers.
      • Moderate and heavy consumers carry the same risk of nephropathy and severe retinopathy as the light consumers.
      • The previous studies have not compared different beverage types. In our study, consumers of alcoholic spirits have a higher risk of both nephropathy and severe retinopathy compared with wine drinkers.
    3. Pathophysiology

      The dynamic changes of zinc transporter 8 autoantibodies in Czech children from the onset of Type 1 diabetes mellitus (pages 165–171)

      L. Petruzelkova, R. Ananieva-Jordanova, J. Vcelakova, Z. Vesely, K. Stechova, J. Lebl, P. Dusatkova, Z. Sumnik, R. Coles, M. Powell, J. Furmaniak, B. Rees Smith and S. Kolouskova

      Article first published online: 13 SEP 2013 | DOI: 10.1111/dme.12308

      What's new?

      • In our study, a new bridging type enzyme-linked immunosorbent assay for zinc transporter 8 (ZnT8) autoantibody measurements was assessed in a large cohort of newly diagnosed Czech children with Type 1 diabetes.
      • We determined the prevalence of ZnT8 autoantibodies in these children at the onset of Type 1 diabetes and followed up with detailed analysis of dynamic changes of serum ZnT8 autoantibody levels over a 10-year (median) period.
      • This study indicates that ZnT8 autoantibody measurements make an important contribution to diagnosis of Type 1 diabetes and help differentiate between different types of diabetes.
    4. Treatment

      Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy (pages 172–175)

      L. A. Distiller, E. S. Polakow and B. I. Joffe

      Article first published online: 18 NOV 2013 | DOI: 10.1111/dme.12342

      What's new?

      • An association of metformin therapy with the prevalence of hypothyroidism in people with Type 2 diabetes has not previously been described.
    5. You have full text access to this OnlineOpen article
      Efficacy and safety of lixisenatide once daily vs. placebo in people with Type 2 diabetes insufficiently controlled on metformin (GetGoal-F1) (pages 176–184)

      G. B. Bolli, M. Munteanu, S. Dotsenko, E. Niemoeller, G. Boka, Y. Wu and M. Hanefeld

      Article first published online: 24 OCT 2013 | DOI: 10.1111/dme.12328

      What's new?

      • Treatment with lixisenatide, when used in a one- or a two-step dose-increase regimen, led to a significant reduction compared with placebo in HbA1c levels at week 24 and during the entire double-blind study period of at least 76 weeks.
      • Tolerability of the one-step dose-increase regimen was at least as good as with the two-step dose-increase regimen.
      • The efficacy and safety of lixisenatide in combination with metformin were confirmed during the main treatment period of 24 weeks and during the entire double-blind study period of at least ≥ 76 weeks.
    6. Complications

      Physiological serum bilirubin concentrations are inversely associated with the prevalence of cardiovascular autonomic neuropathy in patients with Type 2 diabetes (pages 185–191)

      J. O. Chung, D. H. Cho, D. J. Chung and M. Y. Chung

      Article first published online: 15 NOV 2013 | DOI: 10.1111/dme.12338

      What's new?

      • Although normal to modestly elevated bilirubin concentrations have been suggested to be neuroprotective, the relationship between physiological serum bilirubin concentrations and cardiovascular autonomic neuropathy in patients with Type 2 diabetes is currently unknown.
      • Our results show that serum total bilirubin concentrations within the physiologic range are inversely associated with the prevalence of cardiovascular autonomic neuropathy in patients with Type 2 diabetes.
      • Our data suggest that serum total bilirubin levels might be associated with severity of cardiovascular autonomic dysfunction.
    7. Influence of peripheral vascular calcification on efficiency of screening tests for peripheral arterial occlusive disease in diabetes—a cross-sectional study (pages 192–199)

      C. E. Aubert, P. Cluzel, S. Kemel, P.-L. Michel, F. Lajat-Kiss, M. Dadon, A. Hartemann and O. Bourron

      Article first published online: 11 SEP 2013 | DOI: 10.1111/dme.12309

      What's new?

      • We used an objective method for scoring vascular calcification (computed tomography scan) to assess the impact of peripheral vascular calcification on performance of ankle brachial index and pulse palpation.
      • We then assessed the performance of combining ankle brachial index with refined pulse palpation to screen for peripheral arterial occlusive disease in people with diabetes.
      • The high rate of false negative results in screening tests for peripheral arterial occlusive disease is associated with vascular calcification.
      • Screening for peripheral arterial occlusive disease is improved by associating ankle brachial index with refined pulse palpation.
    8. Ethnicity and long-term vascular outcomes in Type 2 diabetes: a prospective observational study (UKPDS 83) (pages 200–207)

      T. M. E. Davis, R. L. Coleman, R. R. Holman and UKPDS Group

      Article first published online: 22 NOV 2013 | DOI: 10.1111/dme.12353

      What's new?

      • In an analysis of pooled longitudinal UK Prospective Diabetes Study data collected from patients with newly diagnosed Type 2 diabetes followed between 1977 and 2007, ethnicity proved to be an important influence on outcome.
      • Compared with the majority White Caucasian group, and after adjusting for major cardiovascular risk factors, Asian Indians with Type 2 diabetes had the greatest number of diabetes-related end points, but had a lower risk of all-cause mortality, while Afro-Caribbean participants were at lower risk of myocardial infarction and death.
      • These data question the need for ethnicity-specific management to improve prognosis and, in the Afro-Caribbean group, suggest novel protective mechanisms that should be investigated further.
    9. Early elevation of albumin excretion rate is associated with poor gluten-free diet adherence in young people with coeliac disease and diabetes (pages 208–212)

      A. Pham-Short, K. C. Donaghue, G. Ambler, A. K. Chan, S. Hing, J. Cusumano and M. E. Craig

      Article first published online: 30 OCT 2013 | DOI: 10.1111/dme.12329

      What's new?

      • There are no studies investigating the effect of gluten-free diet non-adherence in young people with Type 1 diabetes and coeliac disease.
      • This is the first study in young people with Type 1 diabetes with or without coeliac disease, examining the influence of gluten-free diet adherence on complications rates.
      • We report data on 2639 young people with Type 1 diabetes, of whom 129 had coeliac disease. While glycaemic control was better in those with coeliac disease, non-adherence to a gluten-free diet was associated with early elevation of albumin excretion rate, a recognized risk factor for diabetic nephropathy.
      • Our findings support the need for coeliac disease screening and adherence to a gluten-free diet in those with coeliac disease.
    10. Urinary type IV collagen as a predictor for the incidence of microalbuminuria in young patients with Type 1 diabetes (pages 213–218)

      M. Morita, K. Hanai and Y. Uchigata

      Article first published online: 11 NOV 2013 | DOI: 10.1111/dme.12317

      What's new?

      • We longitudinally examined the association of urinary type IV collagen levels with the incidence of microalbuminuria in young patients with Type 1 diabetes.
      • This study has shown that levels of urinary type IV collagen were independently associated with the incidence of microalbuminuria.
    11. Genetics

      A novel single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene (PTPN22) is associated with Type 1 diabetes in a Chinese population (pages 219–226)

      Z. Pei, X. Chen, C. Sun, H. Du, H. Wei, W. Song, Y. Yang, M. Zhang, W. Lu, R. Cheng and F. Luo

      Article first published online: 21 OCT 2013 | DOI: 10.1111/dme.12331

      What's new?

      • Our cohort is the largest Chinese cohort studied to date in this research field.
      • A novel Type 1 diabetes-associated single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene (PTPN22) was identified.
      • Our analysis clearly showed ethnic differences in PTPN22–Type 1 diabetes association compared with other populations.
    12. Educational and Psychological Aspects

      You have free access to this content
      Medical and psychological outcomes for young adults with Type 1 diabetes: no improvement despite recent advances in diabetes care (pages 227–231)

      B. Johnson, J. Elliott, A. Scott, S. Heller and C. Eiser

      Article first published online: 19 SEP 2013 | DOI: 10.1111/dme.12305

      What's new?

      • Despite advances in technology, HbA1c levels are higher than recommended among young adults.
      • Microvascular complications are present in a large proportion of those diagnosed more than 7 years.
      • Depressive symptoms are associated with higher HbA1c levels.
    13. Severe obesity and diabetes self-care attitudes, behaviours and burden: implications for weight management from a matched case-controlled study. Results from Diabetes MILES—Australia (pages 232–240)

      J. B. Dixon, J. L. Browne, K. G. Mosely, T. L. Rice, K. M. Jones, F. Pouwer and J. Speight

      Article first published online: 19 SEP 2013 | DOI: 10.1111/dme.12306

      What's new?

      • This analysis demonstrates, for the first time, that severely obese and non-severely obese (BMI < 35 kg/m2) individuals with Type 2 diabetes differ in their perceptions of diet, physical activity and weight management.
      • Despite more actively trying to lose weight, severely obese individuals placed less importance in, and report greater burden with, diet and exercise recommendations.
      • These differences appear weight-specific and not seen in other diabetes self-care behaviours, including blood glucose monitoring or medication use.
      • Awareness of this additional burden and specific support for weight management is clearly needed to improve diabetes self-care outcomes for severely obese individuals.
    14. You have free access to this content
      General practice-recorded depression and antidepressant use in young people with newly diagnosed Type 1 diabetes: a cohort study using the Clinical Practice Research Datalink (pages 241–245)

      E. Morgan, C. C. Patterson and C. R. Cardwell

      Article first published online: 21 OCT 2013 | DOI: 10.1111/dme.12330

      What's new?

      • Most previous studies on Type 1 diabetes and depression have been cross-sectional in design, with few considering newly diagnosed patients.
      • In 2008, Diabetes UK reported inadequate provision of psychological services for people with diabetes.
      • We compared rates of depression and antidepressant use in a large population-based cohort of people with Type 1 diabetes and matched control subjects.
      • To our knowledge, this is the first study to investigate long-term depression and antidepressant use from diagnosis of Type 1 diabetes, rather than at selected short-term time intervals after diagnosis.
      • Our study highlights that associations vary by time from diabetes diagnosis.
  5. Letters

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letters
    7. Corrections
  6. Corrections

    1. Top of page
    2. Editor's Selection: This Month's Highlighted Articles
    3. Review Article
    4. Systematic Review or Meta-analysis
    5. Research Articles
    6. Letters
    7. Corrections
    1. You have free access to this content
      Corrigendum (page 249)

      Article first published online: 20 JAN 2014 | DOI: 10.1111/dme.12380

      This article corrects:

      Prescription charge exemption and Type 2 diabetes mellitus - a survey of diabetologists' understanding

      Vol. 26, Issue 8, 827–828, Article first published online: 30 MAY 2009

    2. You have free access to this content
      Erratum (page 249)

      Article first published online: 20 JAN 2014 | DOI: 10.1111/dme.12395

      This article corrects:

      Colesevelam for Type 2 diabetes mellitus: an abridged Cochrane review*

      Vol. 31, Issue 1, 2–14, Article first published online: 11 SEP 2013

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