The dynamic changes of zinc transporter 8 autoantibodies in Czech children from the onset of Type 1 diabetes mellitus (pages 165–171)
L. Petruzelkova, R. Ananieva-Jordanova, J. Vcelakova, Z. Vesely, K. Stechova, J. Lebl, P. Dusatkova, Z. Sumnik, R. Coles, M. Powell, J. Furmaniak, B. Rees Smith and S. Kolouskova
Article first published online: 13 SEP 2013 | DOI: 10.1111/dme.12308
- In our study, a new bridging type enzyme-linked immunosorbent assay for zinc transporter 8 (ZnT8) autoantibody measurements was assessed in a large cohort of newly diagnosed Czech children with Type 1 diabetes.
- We determined the prevalence of ZnT8 autoantibodies in these children at the onset of Type 1 diabetes and followed up with detailed analysis of dynamic changes of serum ZnT8 autoantibody levels over a 10-year (median) period.
- This study indicates that ZnT8 autoantibody measurements make an important contribution to diagnosis of Type 1 diabetes and help differentiate between different types of diabetes.