Predicting cognitive ability in ageing cohorts using Type 2 diabetes genetic risk (pages 714–720)
M. Luciano, R. Mõttus, S. E. Harris, G. Davies, A. Payton, W. E. R. Ollier, M. A. Horan, J. M. Starr, D. J. Porteous, N. Pendleton and I. J. Deary
Version of Record online: 30 JAN 2014 | DOI: 10.1111/dme.12389
- The present study investigates whether the relationship between Type 2 diabetes mellitus and lower cognitive ability is attributable to genes predisposing to diabetes.
- Genes predisposing to diabetes (identified from the largest genome-wide association study of Type 2 diabetes to date) were not associated with lower cognitive abilities in older age.
- This suggests that any genetic basis for the association between diabetes and worsened cognition is attributable to those genes that are important for maintaining cognitive ability.
- Alternatively, environmental factors that influence diabetes risk and poorer cognition could explain this association.