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dom12194-sup-0001-AppendixS1.docWord document41KAppendix S1. Primary Investigators for MK-0431/Protocol 102.
dom12194-sup-0002-FigureS1.docWord document496KFigure S1. Study design.
dom12194-sup-0003-FigureS2.docWord document354KFigure S2. Patient disposition. *The randomized population included 283 patients who received overencapsulated (OE) pioglitazone or matching placebo. Prior to unblinding it was decided to exclude these patients from all efficacy analyses based on evidence that OE and non-OE formulations of pioglitazone were not bioequivalent. These patients were also excluded from all analyses relating to safety except the analysis of rates of confirmed, adjudicated cardiovascular adverse events.
dom12194-sup-0004-TableS1.docWord document47KTable S1. Baseline demographic, anthropometric and disease severity characteristics.
dom12194-sup-0005-TableS2.docWord document45KTable S2. Key glycemic endpoints at week 54.
dom12194-sup-0006-TableS3.docWord document32KTable S3. Subgroup analysis, change from baseline at week 24 in A1c in patients with baseline A1c <9.0 and ≥9.0%.
dom12194-sup-0007-TableS4.docWord document42KTable S4. Efficacy comparisons, monotherapy versus combination therapy at week 54.
dom12194-sup-0008-TableS5.docWord document28KTable S5. Percentages of patients meeting A1c goals.
dom12194-sup-0009-TableS6.docWord document47KTable S6. Additional endpoints at week 54.
dom12194-sup-0010-TableS7.docWord document36KTable S7. Efficacy comparisons for additional endpoints at week 54, monotherapy versus combination therapy.
dom12194-sup-0011-TableS8.docWord document34KTable S8. Efficacy comparisons for additional endpoints at week 54, combination therapy versus monotherapy.
dom12194-sup-0012-TableS9.docWord document43KTable S9. Change from baseline in body weight (kg) at week 54.

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