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Prognostic relevance and therapeutic implications of centromere protein F expression in patients with esophageal squamous cell carcinoma

Authors

  • Y.-J. Mi,

    1. Department of Medical Oncology, The 174th Hospital of Chinese P.L.A, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China
    2. Department of Otolaryngology-Head & Neck Surgery, Xiamen First Hospital Affiliated Xiamen University, Xiamen, China
    3. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
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  • J. Gao,

    1. Department of Otolaryngology-Head & Neck Surgery, Xiamen First Hospital Affiliated Xiamen University, Xiamen, China
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  • J.-D. Xie,

    1. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
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  • J.-Y. Cao,

    1. Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China
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  • S.-X. Cui,

    1. Department of Otolaryngology-Head & Neck Surgery, Xiamen First Hospital Affiliated Xiamen University, Xiamen, China
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  • H.-J. Gao,

    1. Department of Otolaryngology-Head & Neck Surgery, Xiamen First Hospital Affiliated Xiamen University, Xiamen, China
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  • S.-P. Yao,

    1. Department of Biostatistics, Jiamusi Medical College, Jiamusi University, Jiamusi, China
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  • T. Liu,

    1. Department of Medical Oncology, The 174th Hospital of Chinese P.L.A, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China
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  • Y.-Y. Zhang,

    1. Department of Medical Oncology, The 174th Hospital of Chinese P.L.A, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China
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  • C.-H. Guo,

    1. Department of Medical Oncology, The 174th Hospital of Chinese P.L.A, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China
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  • G.-Q. Qiu,

    1. Department of Medical Oncology, The 174th Hospital of Chinese P.L.A, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China
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  • Y.-Q. Chen

    Corresponding author
    • Department of Medical Oncology, The 174th Hospital of Chinese P.L.A, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China
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  • Yan-jun Mi and Jing Gao contributed equally to this work.

Address correspondence to: Dr Yu-qiang Chen, MD, Department of Oncology, the 174th Hospital of Chinese P.L.A, the Affiliated Chenggong Hospital of Xiamen University, Xiamen 361003, China. Email: chenyq707@163.com

Summary

Centromere protein F (CENP-F), a cell cycle-regulated centromere protein, has been shown to affect numerous tumorigenic processes. This study aimed to clarify the prognostic significance of CENP-F expression in patients with esophageal squamous cell carcinoma (ESCC). The levels of CENP-F messenger RNA and protein were higher in ESCC cell lines than in the normal tissues. An immunohistochemical analysis of paired tissue specimens showed that the CENP-F expression was higher in tumorous tissues than in the adjacent non-tumorous tissues (P < 0.001). Moreover, there was a significant correlation between CENP-F expression and gender (P = 0.012), clinical stage (P = 0.039), and T classification (P = 0.026). Patients with higher CENP-F expression had shorter overall survival than those with lower CENP-F expression (P = 0.009). Multivariate Cox analysis indicated that CENP-F expression is an independent prognostic factor for overall survival (hazard ratio = 0.582, 95% confidence interval = 0.397–0.804, P = 0.041). Importantly, it was found that zoledronic acid (ZOL) could significantly enhance the chemotherapeutic sensitivity of ESCC cell lines with high CENP-F expression to cisplatin, although ZOL alone only exhibited a minor inhibitory effect to ESCC cells. In summary, these findings demonstrate that CENP-F may serve as a valuable molecular marker for predicting the prognosis of ESCC patients. In addition, the data indicate a potential benefit of combining ZOL with cisplatin in ESCC, suggesting that CENP-F expression may have therapeutic implications.

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