Salicylic Acid Peels Versus Jessner's Solution for Acne Vulgaris: A Comparative Study

Authors

  • Byung Gi Bae MD,

    1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    2. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
    • These authors contributed equally to the study.
  • Chang Ook Park MD,

    1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    2. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
    • These authors contributed equally to the study.
  • Hyoseung Shin MD,

    1. Department of Dermatology, Armed Forces Byukjae Hospital, Goyang, Korea
    Search for more papers by this author
  • Soo Hyun Lee MD,

    1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    2. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Yun Sun Lee MD,

    1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    2. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    3. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Sang Ju Lee MD, PhD,

    1. Yonsei Star Skin & Laser Clinic, Seoul, Korea
    Search for more papers by this author
  • Kee Yang Chung MD, PhD,

    1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    2. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Kwang Hoon Lee MD, PhD,

    1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    2. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    3. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Ju Hee Lee MD, PhD

    Corresponding author
    1. Cutaneous Biology Institute, Yonsei University College of Medicine, Seoul, Korea
    • Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author

  • The authors have indicated no significant interest with commercial supporters.

Address correspondence and reprint requests to: Ju Hee Lee, MD, PhD, Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, 120–752, Korea, or e-mail: juhee@yuhs.ac

Abstract

Background

Salicylic acid was recently formulated in a hydroethanolic vehicle at a concentration of 20% to 30%. Salicylic acid has strong comedolytic effects because of its lipophilic nature.

Objective

To compare the therapeutic efficacy and tolerability of salicylic acid peels with those of Jessner's solution peels in patients with acne vulgaris.

Methods

Thirteen patients (13 men; mean age 22.6, range 20–28) with facial acne were enrolled. Jessner's solution was applied to one side of each patient's face and 30% salicylic acid to the other in three sessions at 2-week intervals. A blinded investigator counted noninflammatory and inflammatory lesions before treatment and 2 weeks after each treatment.

Results

Inflammatory and noninflammatory acne lesion counts decreased in proportion to the duration of treatment. Inflammatory acne lesion counts did not differ significantly between salicylic acid and Jessner's solution peels, although in terms of noninflammatory acne lesion counts, sites treated with salicylic acid showed significant improvement (p = .04), whereas those treated with Jessner's solution did not.

Conclusion

We found that 30% salicylic acid peels were effective for inflammatory acne and more effective than Jessner's solution peels for treating noninflammatory acne.

Ancillary